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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2006-11-9
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pubmed:abstractText |
A series of novel polymeric nanogels with core-shell morphology was developed. Block ionomer complexes of comb-graft poly(ethylene oxide)-b-poly(polypropylene oxide)-b-poly(ethylene oxide)-g-poly(acrylic acid) copolymers (Pluronic-PAA) and divalent metal cations were utilized as micellar templates for the synthesis of nanogels with sizes ranging from 100 to 200 nm in diameter. The Pluronic-PAA nanogels were confirmed to possess ionic cross-linked PAA cores and flexible hydrophilic shells from the Pluronic copolymer chains. The ionic character of the core provided for pH-dependent swelling/collapse behavior of the nanogels. These prepared nanogels are expected to be of utility as carriers for charged therapeutic or diagnostic agents.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acrylates,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Chloride,
http://linkedlifedata.com/resource/pubmed/chemical/Colloids,
http://linkedlifedata.com/resource/pubmed/chemical/Cross-Linking Reagents,
http://linkedlifedata.com/resource/pubmed/chemical/Edetic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Micelles,
http://linkedlifedata.com/resource/pubmed/chemical/NanoGel,
http://linkedlifedata.com/resource/pubmed/chemical/Poloxamer,
http://linkedlifedata.com/resource/pubmed/chemical/Polyethylene Glycols,
http://linkedlifedata.com/resource/pubmed/chemical/Polyethyleneimine,
http://linkedlifedata.com/resource/pubmed/chemical/Polymers,
http://linkedlifedata.com/resource/pubmed/chemical/acrylic acid
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1061-186X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
357-66
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:17092836-Acrylates,
pubmed-meshheading:17092836-Calcium Chloride,
pubmed-meshheading:17092836-Colloids,
pubmed-meshheading:17092836-Cross-Linking Reagents,
pubmed-meshheading:17092836-Edetic Acid,
pubmed-meshheading:17092836-Hydrogen-Ion Concentration,
pubmed-meshheading:17092836-Hydrophobic and Hydrophilic Interactions,
pubmed-meshheading:17092836-Micelles,
pubmed-meshheading:17092836-Microscopy, Atomic Force,
pubmed-meshheading:17092836-Models, Theoretical,
pubmed-meshheading:17092836-Nanoparticles,
pubmed-meshheading:17092836-Nephelometry and Turbidimetry,
pubmed-meshheading:17092836-Osmolar Concentration,
pubmed-meshheading:17092836-Poloxamer,
pubmed-meshheading:17092836-Polyethylene Glycols,
pubmed-meshheading:17092836-Polyethyleneimine,
pubmed-meshheading:17092836-Polymers,
pubmed-meshheading:17092836-Technology, Pharmaceutical
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pubmed:year |
2006
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pubmed:articleTitle |
Template-assisted synthesis of nanogels from Pluronic-modified poly(acrylic acid).
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pubmed:affiliation |
Department of Pharmaceutical Sciences and Center for Drug Delivery and Nanomedicine, College of Pharmacy, University of Nebraska Medical Center, 985830 Nebraska Medical Center, Omaha, NE 68198-5830, USA. tbronich@unmc.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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