Linked Life Data

1709180

Source:http://linkedlifedata.com/resource/pubmed/id/1709180

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1991-6-7
pubmed:abstractText
The present study was carried out to analyze the topography of spinal projections to the anterior and posterior lobes of the cerebellum and to investigate whether projections to the two lobes come from different spinocerebellar neurons or from branching axons of the same cells. We used orthograde transport of horseradish peroxidase conjugated with wheat germ agglutinin (WGA-HRP) to identify the cerebellar areas where spinocerebellar axons terminate and retrograde double-labeling techniques to estimate the incidence of spinocerebellar neurons projecting to both anterior and posterior lobes via axon collaterals. Orthograde labeling confirmed that the rat, like other mammalian species, has spinocerebellar projections to two different regions of cerebellar cortex, i.e., lobules I-V of the anterior lobe and lobule VIII of the posterior lobe, with the highest incidence in lobules II, III, and VIII. We did not observe a clear difference in the distribution of afferents coming from different spinal segments to either of the two lobes. The double-labeled cells were located primarily in the lower thoracic and upper lumbar segments, almost exclusively in Clarke's column and in the dorso-lateral part of lamina 7 (in the region of the spinal border cells). It is likely that most or all of the spinocerebellar neurons in these structures project to both anterior and posterior lobes. Therefore, the two lobes of the cerebellum are likely to receive common information from these cells, but different information from the separate populations of spinocerebellar neurons that project only to one lobe or the other.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0021-9967
pubmed:author
pubmed:issnType
Print
pubmed:day
8
pubmed:volume
305
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
273-81
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Origin of spinal projections to the anterior and posterior lobes of the rat cerebellum.
pubmed:affiliation
Institute of Human Physiology, University of Catania, Italy.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't