| pubmed-article:1709046 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1709046 | lifeskim:mentions | umls-concept:C0567416 | lld:lifeskim |
| pubmed-article:1709046 | lifeskim:mentions | umls-concept:C0312738 | lld:lifeskim |
| pubmed-article:1709046 | lifeskim:mentions | umls-concept:C1306673 | lld:lifeskim |
| pubmed-article:1709046 | lifeskim:mentions | umls-concept:C2756019 | lld:lifeskim |
| pubmed-article:1709046 | lifeskim:mentions | umls-concept:C0971887 | lld:lifeskim |
| pubmed-article:1709046 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:1709046 | pubmed:dateCreated | 1991-6-12 | lld:pubmed |
| pubmed-article:1709046 | pubmed:abstractText | Specific binding of antigens to the surface immunoglobulin M (sIgM) triggers B cells with several biochemical events involved in receptor-mediated signal transmission for proliferation and differentiation into antibody-producing cells. Recent studies with the Digitonin lysis method identified the sIgM-associated component, IgM-alpha (B34)/Ig-beta, as the possible candidate for the transducer molecule(s) in the immunoglobulin receptor-mediated signal transmission. The 34 kd protein (B34 or IgM-alpha) of this component is suggested to be encoded by the B cell-specific mb-1 gene. We prepared monoclonal antibodies which recognize the mb-1 gene product (MB-1) and studied the functional role of MB-1 in the signal transmission in B lineage cells. Using murine pre-B lymphoma cells (18-81 and 70Z/3), we demonstrated the early phase increase of the intracellular [Ca2+]i concentration and the subsequent inhibition of the proliferation by the monoclonal anti-MB-1 antibody (11-18-5). These results clearly demonstrate signal transmission through the surface MB-1 molecule on B lineage lymphomas. This MB-1-mediated signal transmission in pre-B cell lines would suggest an alternative function of MB-1 acting at the pre-B cell stage. | lld:pubmed |
| pubmed-article:1709046 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1709046 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1709046 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1709046 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1709046 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1709046 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1709046 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1709046 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:1709046 | pubmed:issn | 0953-8178 | lld:pubmed |
| pubmed-article:1709046 | pubmed:author | pubmed-author:MatsuoTT | lld:pubmed |
| pubmed-article:1709046 | pubmed:author | pubmed-author:NomuraJJ | lld:pubmed |
| pubmed-article:1709046 | pubmed:author | pubmed-author:KubotaEE | lld:pubmed |
| pubmed-article:1709046 | pubmed:author | pubmed-author:KimotoMM | lld:pubmed |
| pubmed-article:1709046 | pubmed:author | pubmed-author:SakaguchiNN | lld:pubmed |
| pubmed-article:1709046 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1709046 | pubmed:volume | 3 | lld:pubmed |
| pubmed-article:1709046 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1709046 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1709046 | pubmed:pagination | 117-26 | lld:pubmed |
| pubmed-article:1709046 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:1709046 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1709046 | pubmed:articleTitle | Signal transmission through the B cell-specific MB-1 molecule at the pre-B cell stage. | lld:pubmed |
| pubmed-article:1709046 | pubmed:affiliation | Department of Immunology, Saga Medical School, Japan. | lld:pubmed |
| pubmed-article:1709046 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1709046 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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