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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
21
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pubmed:dateCreated |
2006-11-22
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pubmed:abstractText |
Both the A1- and A3-adenosine receptors (ARs) have been implicated in mediating the cardioprotective effects of adenosine. Paradoxically, overexpression of both A1-AR and A3-AR is associated with changes in the cardiac phenotype. To evaluate the temporal relationship between AR signaling and cardiac remodeling, we studied the effects of controlled overexpression of the A1-AR using a cardiac-specific and tetracycline-transactivating factor-regulated promoter.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1524-4539
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pubmed:author |
pubmed-author:ChanTung OTO,
pubmed-author:ChenXiongwenX,
pubmed-author:FeldmanArthur MAM,
pubmed-author:FunakoshiHajimeH,
pubmed-author:GoodJulie CJC,
pubmed-author:HerrmannDavid EDE,
pubmed-author:HouserSteven RSR,
pubmed-author:KochWalter JWJ,
pubmed-author:LeeLing LLL,
pubmed-author:LibonatiJoseph RJR,
pubmed-author:MacDonnellScott MSM,
pubmed-author:MartiniJeffreyJ,
pubmed-author:PalmerTimothy MTM,
pubmed-author:PiuholaJarkkoJ,
pubmed-author:RobbinsJeffreyJ,
pubmed-author:SanbeAtsushiA,
pubmed-author:ZhangJinJ
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pubmed:issnType |
Electronic
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pubmed:day |
21
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pubmed:volume |
114
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2240-50
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17088462-Animals,
pubmed-meshheading:17088462-Cardiomegaly,
pubmed-meshheading:17088462-Cardiomyopathy, Dilated,
pubmed-meshheading:17088462-Doxycycline,
pubmed-meshheading:17088462-Echocardiography,
pubmed-meshheading:17088462-Electrocardiography,
pubmed-meshheading:17088462-Fibrosis,
pubmed-meshheading:17088462-Gene Expression,
pubmed-meshheading:17088462-Heart,
pubmed-meshheading:17088462-Heart Rate,
pubmed-meshheading:17088462-Humans,
pubmed-meshheading:17088462-Hypertension,
pubmed-meshheading:17088462-Mice,
pubmed-meshheading:17088462-Mice, Transgenic,
pubmed-meshheading:17088462-Myocardium,
pubmed-meshheading:17088462-Phosphorylation,
pubmed-meshheading:17088462-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:17088462-Receptor, Adenosine A1,
pubmed-meshheading:17088462-Survival Analysis,
pubmed-meshheading:17088462-Time Factors
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pubmed:year |
2006
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pubmed:articleTitle |
Regulated overexpression of the A1-adenosine receptor in mice results in adverse but reversible changes in cardiac morphology and function.
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pubmed:affiliation |
Center for Translational Medicine, Department of Medicine, Jefferson Medical College, Philadelphia, PA 19107, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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