Linked Life Data

17086392

Source:http://linkedlifedata.com/resource/pubmed/id/17086392

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2007-3-5
pubmed:abstractText
BACKGROUND: This review discusses evidence that cells in the mesocortical dopamine (DA) system influence information processing in target areas across three distinct temporal domains. DISCUSSIONS: Phasic bursting of midbrain DA neurons may provide temporally precise information about the mismatch between expected and actual rewards (prediction errors) that has been hypothesized to serve as a learning signal in efferent regions. However, because DA acts as a relatively slow modulator of cortical neurotransmission, it is unclear whether DA can indeed act to precisely transmit prediction errors to prefrontal cortex (PFC). In light of recent physiological and anatomical evidence, we propose that corelease of glutamate from DA and/or non-DA neurons in the VTA could serve to transmit this temporally precise signal. In contrast, DA acts in a protracted manner to provide spatially and temporally diffuse modulation of PFC pyramidal neurons and interneurons. This modulation occurs first via a relatively rapid depolarization of fast-spiking interneurons that acts on the order of seconds. This is followed by a more protracted modulation of a variety of other ionic currents on timescales of minutes to hours, which may bias the manner in which cortical networks process information. However, the prolonged actions of DA may be curtailed by counteracting influences, which likely include opposing actions at D1 and D2-like receptors that have been shown to be time- and concentration-dependent. In this way, the mesocortical DA system optimizes the characteristics of glutamate, GABA, and DA neurotransmission both within the midbrain and cortex to communicate temporally precise information and to modulate network activity patterns on prolonged timescales.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0033-3158
pubmed:author
pubmed:issnType
Print
pubmed:volume
191
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
609-25
pubmed:dateRevised
2007-12-3
pubmed:meshHeading
pubmed-meshheading:17086392-Animals, pubmed-meshheading:17086392-Cognition, pubmed-meshheading:17086392-Dopamine, pubmed-meshheading:17086392-Excitatory Amino Acid Agonists, pubmed-meshheading:17086392-Excitatory Amino Acid Antagonists, pubmed-meshheading:17086392-Glutamic Acid, pubmed-meshheading:17086392-Humans, pubmed-meshheading:17086392-Interneurons, pubmed-meshheading:17086392-Learning, pubmed-meshheading:17086392-Mesencephalon, pubmed-meshheading:17086392-Neural Conduction, pubmed-meshheading:17086392-Neural Pathways, pubmed-meshheading:17086392-Neurotransmitter Agents, pubmed-meshheading:17086392-Prefrontal Cortex, pubmed-meshheading:17086392-Pyramidal Cells, pubmed-meshheading:17086392-Receptors, Dopamine, pubmed-meshheading:17086392-Reward, pubmed-meshheading:17086392-Synaptic Transmission, pubmed-meshheading:17086392-Time Factors, pubmed-meshheading:17086392-Ventral Tegmental Area, pubmed-meshheading:17086392-gamma-Aminobutyric Acid
pubmed:year
2007
pubmed:articleTitle
The ability of the mesocortical dopamine system to operate in distinct temporal modes.
pubmed:affiliation
Department of Neurosciences, Medical University of South Carolina, Suite 430 BSB 173 Ashley, Charleston, SC, USA. lapishc@musc.edu
pubmed:publicationType
Journal Article, Review, Research Support, N.I.H., Extramural