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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:dateCreated |
1991-5-23
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pubmed:abstractText |
The reported inverse relationship between fractional urinary clearance of lithium (FCLi) and erythrocyte sodium-lithium countertransport (Na-Li CT) in normotensive and hypertensive subjects suggests that Na-Li CT may be a marker of proximal tubular sodium reabsorption. We have refuted this hypothesis in a multiracial study of 57 Caucasian and 48 Maori normotensive and hypertensive males aged 20-40 years. Na-Li CT was measured in vitro by standard Li efflux methodology, and in vivo by the Li cell:plasma (Li C:P) ratio 24 h after a 1 g oral dose of lithium carbonate. The Na-Li CT and Li C:P ratio were not significantly different in the two races and were strongly correlated within race, confirming the validity of the Li C:P ratio as an in vivo index of in vitro Na-Li CT. There was no correlation in either race between in vitro or in vivo erythrocyte membrane sodium transport indices and FCLi.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0160-2446
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
16 Suppl 7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
S50-1
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1708024-Adult,
pubmed-meshheading:1708024-Biological Markers,
pubmed-meshheading:1708024-Blood Pressure,
pubmed-meshheading:1708024-Erythrocytes,
pubmed-meshheading:1708024-Humans,
pubmed-meshheading:1708024-Kidney Tubules, Proximal,
pubmed-meshheading:1708024-Lithium,
pubmed-meshheading:1708024-Male,
pubmed-meshheading:1708024-Sodium
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pubmed:year |
1990
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pubmed:articleTitle |
Sodium-lithium countertransport is not a marker of proximal tubular sodium clearance.
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pubmed:affiliation |
Department of Medicine, Wellington School of Medicine, New Zealand.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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