Linked Life Data

17073624

Source:http://linkedlifedata.com/resource/pubmed/id/17073624

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
23
pubmed:dateCreated
2006-10-31
pubmed:abstractText
T cell receptors are among the most specific biological structures found in nature and are therefore excellent candidates for the molecular targeting of antigen. It is becoming increasingly apparent that common sets of T cell receptors are frequently used in humans to combat pathogen and cancer derived threats. Given that many of these conserved T cell receptors have high affinity for their target ligands, there is potential to amass virtual banks of "off-the-shelf" receptors for use in a wide range of immunotherapeutic strategies. Additionally, such T cell receptors could become basic blueprints for artificial enhancement through mutagenesis, thereby creating an even better 3-dimensional fit for their cognate targets. Indeed, preliminary approaches using both "natural" and "supernatural" T cell receptors have shown promise in treating autoimmunity and malignancy. This review will discuss these studies and other approaches through which T cell receptors can be exploited in immunodiagnostics, pathogen control and gene therapy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0929-8673
pubmed:author
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2725-36
pubmed:dateRevised
2007-2-12
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Engineered T cell receptors and their potential in molecular medicine.
pubmed:affiliation
Cellular Immunology Laboratory, Queensland Institute of Medical Research, Herston 4029, Queensland, Australia.
pubmed:publicationType
Journal Article, Review