Source:http://linkedlifedata.com/resource/pubmed/id/17066299
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2007-1-19
|
| pubmed:abstractText |
The structural microheterogeneity evident between the human and chimpanzee genomes is quite considerable and includes inversions and duplications as well as deletions, ranging in size from a few base-pairs up to several megabases (Mb). Insertions and deletions have together given rise to at least 150 Mb of genomic DNA sequence that is either present or absent in humans as compared to chimpanzees. Such regions often contain paralogous sequences and members of multigene families thereby ensuring that the human and chimpanzee genomes differ by a significant fraction of their gene content. There is as yet no evidence to suggest that the large chromosomal rearrangements which serve to distinguish the human and chimpanzee karyotypes have influenced either speciation or the evolution of lineage-specific traits. However, the myriad submicroscopic rearrangements in both genomes, particularly those involving copy number variation, are unlikely to represent exclusively neutral changes and hence promise to facilitate the identification of genes that have been important for human-specific evolution.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0340-6717
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
120
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
759-78
|
| pubmed:dateRevised |
2009-11-19
|
| pubmed:meshHeading |
pubmed-meshheading:17066299-Animals,
pubmed-meshheading:17066299-Chromosome Inversion,
pubmed-meshheading:17066299-DNA,
pubmed-meshheading:17066299-DNA Transposable Elements,
pubmed-meshheading:17066299-Evolution, Molecular,
pubmed-meshheading:17066299-Female,
pubmed-meshheading:17066299-Gene Dosage,
pubmed-meshheading:17066299-Gene Rearrangement,
pubmed-meshheading:17066299-Genome, Human,
pubmed-meshheading:17066299-Humans,
pubmed-meshheading:17066299-Karyotyping,
pubmed-meshheading:17066299-Male,
pubmed-meshheading:17066299-Models, Genetic,
pubmed-meshheading:17066299-Multigene Family,
pubmed-meshheading:17066299-Pan troglodytes,
pubmed-meshheading:17066299-Recombination, Genetic,
pubmed-meshheading:17066299-Sequence Deletion,
pubmed-meshheading:17066299-Sex Chromosomes,
pubmed-meshheading:17066299-Species Specificity,
pubmed-meshheading:17066299-Telomere
|
| pubmed:year |
2007
|
| pubmed:articleTitle |
Structural divergence between the human and chimpanzee genomes.
|
| pubmed:affiliation |
Department of Human Genetics, University of Ulm, Ulm, Germany. hildegard.kehrer-sawatzki@uni-ulm.de
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Review
|