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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2006-10-26
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pubmed:abstractText |
Numerous experimental and clinical studies suggest that brief opioid exposure can enhance pain sensitivity. It is suggested that spinal cyclooxygenase activity may contribute to the development and expression of opioid tolerance. The aim of the investigation was to determine analgesic and antihyperalgesic properties of the cyclooxygenase-2 inhibitor parecoxib on remifentanil-induced hypersensitivity in humans.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0003-3022
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
105
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1016-23
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pubmed:meshHeading |
pubmed-meshheading:17065897-Adult,
pubmed-meshheading:17065897-Analgesia,
pubmed-meshheading:17065897-Analgesics, Opioid,
pubmed-meshheading:17065897-Cyclooxygenase Inhibitors,
pubmed-meshheading:17065897-Double-Blind Method,
pubmed-meshheading:17065897-Drug Interactions,
pubmed-meshheading:17065897-Humans,
pubmed-meshheading:17065897-Hyperalgesia,
pubmed-meshheading:17065897-Infusions, Intravenous,
pubmed-meshheading:17065897-Isoxazoles,
pubmed-meshheading:17065897-Ketamine,
pubmed-meshheading:17065897-Male,
pubmed-meshheading:17065897-Middle Aged,
pubmed-meshheading:17065897-Pain Threshold,
pubmed-meshheading:17065897-Piperidines
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pubmed:year |
2006
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pubmed:articleTitle |
Modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by parecoxib in humans.
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pubmed:affiliation |
Department of Anesthesiology, University Hospital Erlangen, Erlangen, Germany.
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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