Linked Life Data

17064050

Source:http://linkedlifedata.com/resource/pubmed/id/17064050

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
22
pubmed:dateCreated
2006-10-26
pubmed:abstractText
Conversion of an alpha,alpha-dichloroester to the corresponding alpha-keto acid was unexpectedly complicated by a novel 1,4-homofragmentation. Investigation of the kinetics of this reaction revealed a mechanism involving an alpha-lactone intermediate, which can lead to both the desired alpha-keto acid and the 1,4-homofragmentation, with the product distribution being dependent upon reaction conditions. This information allowed development of a process that affords the alpha-keto acid exclusively and should be generally applicable to the preparation of alpha-keto acids from alpha,alpha-dichloroesters or acids.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0022-3263
pubmed:author
pubmed:issnType
Print
pubmed:day
27
pubmed:volume
71
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
8647-50
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Novel 1,4-homofragmentation via an alpha-lactone.
pubmed:affiliation
Department of Process Research and Development, Pharmaceutical Research Institute, Bristol-Myers Squibb, Post Office Box 4000, Princeton, New Jersey 08543-4000, USA. jollie.godfrey@bms.com
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't