|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1-3
|
|
pubmed:dateCreated |
2006-11-6
|
|
pubmed:abstractText |
Felbamate (2-phenyl-1,3-propanediol dicarbamate) is clinically available for the treatment of refractory epileptic seizures, and is known to modulate several ion channels including gamma-aminobutyric acid type A (GABA(A)) receptors. To determine felbamate subunit selectivity for GABA(A) receptors we expressed 15 different GABA(A) receptor combinations in Xenopus laevis oocytes. Felbamate positively modulated GABA-currents of alpha(1)beta(2)gamma(2S), alpha(1)beta(3)gamma(2S), alpha(2)beta(2)gamma(2S) and alpha(2)beta(3)gamma(2S), whereas felbamate was either ineffective or negatively modulated the other 11 receptor combinations. Regional distributions of GABA(A) receptor subunits suggest that felbamate may differentially modulate distinct inhibitory circuits, a possibility that may have relevance to felbamate efficacy in refractory epilepsies.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Recombinant,
http://linkedlifedata.com/resource/pubmed/chemical/Diazepam,
http://linkedlifedata.com/resource/pubmed/chemical/Flumazenil,
http://linkedlifedata.com/resource/pubmed/chemical/GABA Modulators,
http://linkedlifedata.com/resource/pubmed/chemical/Phenylcarbamates,
http://linkedlifedata.com/resource/pubmed/chemical/Propylene Glycols,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Subunits,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, GABA-A,
http://linkedlifedata.com/resource/pubmed/chemical/felbamate,
http://linkedlifedata.com/resource/pubmed/chemical/gamma-Aminobutyric Acid
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
0014-2999
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
15
|
|
pubmed:volume |
552
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
31-5
|
|
pubmed:dateRevised |
2007-12-3
|
|
pubmed:meshHeading |
pubmed-meshheading:17056029-Animals,
pubmed-meshheading:17056029-Cells, Cultured,
pubmed-meshheading:17056029-Cerebellum,
pubmed-meshheading:17056029-DNA, Recombinant,
pubmed-meshheading:17056029-Diazepam,
pubmed-meshheading:17056029-Female,
pubmed-meshheading:17056029-Flumazenil,
pubmed-meshheading:17056029-GABA Modulators,
pubmed-meshheading:17056029-Gene Expression,
pubmed-meshheading:17056029-Humans,
pubmed-meshheading:17056029-Membrane Potentials,
pubmed-meshheading:17056029-Oocytes,
pubmed-meshheading:17056029-Patch-Clamp Techniques,
pubmed-meshheading:17056029-Phenylcarbamates,
pubmed-meshheading:17056029-Plasmids,
pubmed-meshheading:17056029-Propylene Glycols,
pubmed-meshheading:17056029-Protein Subunits,
pubmed-meshheading:17056029-Receptors, GABA-A,
pubmed-meshheading:17056029-Xenopus laevis,
pubmed-meshheading:17056029-gamma-Aminobutyric Acid
|
|
pubmed:year |
2006
|
|
pubmed:articleTitle |
Felbamate is a subunit selective modulator of recombinant gamma-aminobutyric acid type A receptors expressed in Xenopus oocytes.
|
|
pubmed:affiliation |
Interdepartmental Program in Neuroscience, University of Utah, Salt Lake City, UT 84112-9057, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
|
