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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2006-11-19
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pubmed:abstractText |
Pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) and granulocyte colony-stimulating factor (G-CSF) promote haematopoietic progenitor cell maturation. We reviewed the findings for healthy volunteers/donors who developed haematological malignancies following PEG-rHuMGDF or G-CSF administration. Information was reviewed for three of 538 volunteers who received PEG-rHuMGDF in clinical trials and two of 200 donors who underwent G-CSF mobilised stem cell harvesting procedures for sibling stem cell transplants. Mantle cell, diffuse large B-cell lymphoma and chronic lymphocytic leukaemia were diagnosed 1-5 years after PEG-rHuMGDF exposure among three volunteers. For one patient, thrombocytopenia due to autoantibodies to PEG-rHuMGDF developed shortly after PEG-rHuMGDF administration and persisted until chemotherapy was administered. All three achieved complete remission, although one patient relapsed. Acute myeloid leukaemia was diagnosed 4 and 5 years after G-CSF mobilisation in two donors who underwent peripheral blood stem cell donation for sibling allogeneic haematopoietic stem cell transplantation. Following intensive chemotherapy, one died from acute leukaemia and the second is in complete remission. Controversy exists over the appropriateness of administering haematopoietic growth factors to healthy individuals. While a causal relationship with haematological malignancies cannot be demonstrated, long-term follow-up among healthy individuals who receive haematopoietic growth factors is needed.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0007-1048
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pubmed:author |
pubmed-author:AndritsosLeslie ALA,
pubmed-author:AngelottaCaraC,
pubmed-author:BalasubramanianLakshmiL,
pubmed-author:BennettCharles LCL,
pubmed-author:BiermanPhilip JPJ,
pubmed-author:DevineSteven MSM,
pubmed-author:EvensAndrew MAM,
pubmed-author:FisherMatthew JMJ,
pubmed-author:KuterDavid JDJ,
pubmed-author:KuzelTimothy MTM,
pubmed-author:LynnR CRC,
pubmed-author:McKoyJune MJM,
pubmed-author:TallmanMartin SMS,
pubmed-author:TrifilioSteven MSM,
pubmed-author:VoseJulie MJM
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pubmed:issnType |
Print
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pubmed:volume |
135
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
642-50
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:17054431-Adult,
pubmed-meshheading:17054431-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:17054431-Autoantibodies,
pubmed-meshheading:17054431-Clinical Trials as Topic,
pubmed-meshheading:17054431-Female,
pubmed-meshheading:17054431-Granulocyte Colony-Stimulating Factor,
pubmed-meshheading:17054431-Hematologic Neoplasms,
pubmed-meshheading:17054431-Hematopoietic Cell Growth Factors,
pubmed-meshheading:17054431-Humans,
pubmed-meshheading:17054431-Leukemia, Erythroblastic, Acute,
pubmed-meshheading:17054431-Leukemia, Lymphocytic, Chronic, B-Cell,
pubmed-meshheading:17054431-Leukemia, Monocytic, Acute,
pubmed-meshheading:17054431-Lymphoma, B-Cell,
pubmed-meshheading:17054431-Lymphoma, Mantle-Cell,
pubmed-meshheading:17054431-Male,
pubmed-meshheading:17054431-Middle Aged,
pubmed-meshheading:17054431-Peripheral Blood Stem Cell Transplantation,
pubmed-meshheading:17054431-Polyethylene Glycols,
pubmed-meshheading:17054431-Recombinant Proteins,
pubmed-meshheading:17054431-Thrombopoietin,
pubmed-meshheading:17054431-Tissue Donors
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pubmed:year |
2006
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pubmed:articleTitle |
Haematological malignancies developing in previously healthy individuals who received haematopoietic growth factors: report from the Research on Adverse Drug Events and Reports (RADAR) project.
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pubmed:affiliation |
VA Midwest Center for Health Services and Policy Research, the Jesse Brown VA Medical Center, Chicago, IL, USA. cbenne@northwestern.edu
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pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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