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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1991-3-28
|
| pubmed:abstractText |
Prostaglandin synthesis by astrocytes in culture has been shown to be stimulated by a range of mediators including ATP, interleukin-1 and the neuropeptide substance P. In this paper we present evidence that astrocytes from rat spinal cord, but not other CNS regions, release prostaglandins in response to treatment with sub-micromolar concentrations of the neuropeptide substance P, a neuromodulator that may be involved in regulating the input of nociceptive information into the spinal cord. This in vitro phenomenon, if representative of physiological responses, suggests that astrocytes may play a role in central processing of noxious input. The fact that astrocytes from rat cortex do not exhibit substance P-evoked prostanoid release provides further evidence for regional astrocyte heterogeneity.
|
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0732-8141
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
21B
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
739-41
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| pubmed:dateRevised |
2003-11-14
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| pubmed:meshHeading | |
| pubmed:year |
1991
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| pubmed:articleTitle |
Eicosanoid synthesis by spinal cord astrocytes is evoked by substance P; possible implications for nociception and pain.
|
| pubmed:affiliation |
Biochemistry Department, Imperial College, London.
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| pubmed:publicationType |
Journal Article
|