Linked Life Data

17047456

Source:http://linkedlifedata.com/resource/pubmed/id/17047456

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
16
pubmed:dateCreated
2006-10-18
pubmed:abstractText
We investigated, during the first postnatal week, a voltage-gated sodium current (INa) transiently expressed in neonatal utricular hair cells in rats raised in hypergravity. Its electrophysiological properties did not differ significantly from those recorded from rats raised in normal gravity, but a delay was observed in their developmental expression. In normal gravity conditions, INa expression is maximal at postnatal days 1-2, conferring on the hair cells the ability to fire action potentials, and is down-regulated during the first postnatal week, whereas in hypergravity conditions, the down-regulation is delayed by 4 days. This is the first demonstration showing that development under enhanced gravity affects the transient excitability phase that characterizes neonate utricular hair cells, by delaying a critical period of vestibular development.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0959-4965
pubmed:author
pubmed:issnType
Print
pubmed:day
6
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1697-701
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Hypergravity affects the developmental expression of voltage-gated sodium current in utricular hair cells.
pubmed:affiliation
I.N.S.E.R.M. U 583, Montpellier Institute for Neurosciences, Department of Pathophysiology and Therapy of the Inner Ear, Research Group on Vestibular Disorders, Hôpital St Eloi, Montpellier Cedex, France. abrugeaud@univ-montp2.fr
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't