Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-3
pubmed:dateCreated
2006-11-6
pubmed:abstractText
By comprehensive and detailed measurement of the time course of withdrawal signs in rats, Joyce et al. (J. Theo. Biol. 240:531-537, 2006) recently provided a creative quantitative model of the onset of drug dependence based on the requirement of protein synthesis. Because the initial model fit the data imperfectly over the full time course, those authors postulated that additional features would be needed. We report excellent fit of the data (R(2)=0.96) by adding: (1) a transient early phase, and (2) a delay in the buildup of protein.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/17045985-10774721, http://linkedlifedata.com/resource/pubmed/commentcorrection/17045985-11295319, http://linkedlifedata.com/resource/pubmed/commentcorrection/17045985-11543871, http://linkedlifedata.com/resource/pubmed/commentcorrection/17045985-12098591, http://linkedlifedata.com/resource/pubmed/commentcorrection/17045985-12397092, http://linkedlifedata.com/resource/pubmed/commentcorrection/17045985-12486185, http://linkedlifedata.com/resource/pubmed/commentcorrection/17045985-12827149, http://linkedlifedata.com/resource/pubmed/commentcorrection/17045985-14328896, http://linkedlifedata.com/resource/pubmed/commentcorrection/17045985-14662727, http://linkedlifedata.com/resource/pubmed/commentcorrection/17045985-4378655, http://linkedlifedata.com/resource/pubmed/commentcorrection/17045985-4570065, http://linkedlifedata.com/resource/pubmed/commentcorrection/17045985-5408607, http://linkedlifedata.com/resource/pubmed/commentcorrection/17045985-5413284, http://linkedlifedata.com/resource/pubmed/commentcorrection/17045985-566320, http://linkedlifedata.com/resource/pubmed/commentcorrection/17045985-8375615, http://linkedlifedata.com/resource/pubmed/commentcorrection/17045985-9311926, http://linkedlifedata.com/resource/pubmed/commentcorrection/17045985-9311927, http://linkedlifedata.com/resource/pubmed/commentcorrection/17045985-9716929
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
3
pubmed:volume
551
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
54-7
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Modified 'Joyce model' of opioid dependence/withdrawal.
pubmed:affiliation
Temple University School of Pharmacy, Department of Pharmaceutical Sciences, Philadelphia PA 19140, USA. robert.raffa@temple.edu
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural