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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2006-10-18
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pubmed:abstractText |
Using a mouse model of human acute myeloid leukemia (AML) induced by the MLL-AF9 oncogene, we demonstrate that colony-forming cells (CFCs) in the bone marrow and spleen of leukemic mice are also leukemia stem cells (LSCs). These self-renewing cells (1) are frequent, accounting for 25%-30% of myeloid lineage cells at late-stage disease; (2) generate a phenotypic, morphologic, and functional leukemia cell hierarchy; (3) express mature myeloid lineage-specific antigens; and (4) exhibit altered microenvironmental interactions by comparison with the oncogene-immortalized CFCs that initiated the disease. Therefore, the LSCs responsible for sustaining, expanding, and regenerating MLL-AF9 AML are downstream myeloid lineage cells, which have acquired an aberrant Hox-associated self-renewal program as well as other biologic features of hematopoietic stem cells.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1535-6108
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
257-68
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17045204-Animals,
pubmed-meshheading:17045204-Bone Marrow Cells,
pubmed-meshheading:17045204-Cell Culture Techniques,
pubmed-meshheading:17045204-Cell Line, Transformed,
pubmed-meshheading:17045204-Cell Lineage,
pubmed-meshheading:17045204-Cell Transformation, Neoplastic,
pubmed-meshheading:17045204-Coculture Techniques,
pubmed-meshheading:17045204-Culture Media, Conditioned,
pubmed-meshheading:17045204-Disease Models, Animal,
pubmed-meshheading:17045204-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:17045204-Hematopoietic Stem Cells,
pubmed-meshheading:17045204-Humans,
pubmed-meshheading:17045204-Immunophenotyping,
pubmed-meshheading:17045204-Leukemia, Experimental,
pubmed-meshheading:17045204-Leukemia, Myeloid, Acute,
pubmed-meshheading:17045204-Mice,
pubmed-meshheading:17045204-Mice, Inbred C57BL,
pubmed-meshheading:17045204-Mice, Inbred Strains,
pubmed-meshheading:17045204-Mice, Transgenic,
pubmed-meshheading:17045204-Myeloid Cells,
pubmed-meshheading:17045204-Oncogene Proteins, Fusion,
pubmed-meshheading:17045204-Proto-Oncogene Proteins c-kit,
pubmed-meshheading:17045204-Retroviridae,
pubmed-meshheading:17045204-Spleen,
pubmed-meshheading:17045204-Transduction, Genetic,
pubmed-meshheading:17045204-Transplantation, Homologous,
pubmed-meshheading:17045204-X-Rays
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pubmed:year |
2006
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pubmed:articleTitle |
Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia.
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pubmed:affiliation |
Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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