Linked Life Data

17041900

Source:http://linkedlifedata.com/resource/pubmed/id/17041900

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2006-10-19
pubmed:abstractText
Morphogenetic fields are among the most fundamental concepts of embryology. However, they are also among the most ill-defined, since they consist of dynamic regulatory processes whose exact nature remains elusive. In order to achieve a more rigorous definition of a developmental field, Lewis Wolpert introduced the concept of positional information illustrated by his French Flag model. Here we argue that Wolpert's positional information - a static coordinate system defining a field - lacks essential properties of the original field concept. We show how data-driven mathematical modeling approaches now enable us to study regulatory processes in a way that is qualitatively different from our previous level of understanding. As an example, we review our recent analysis of segmentation gene expression in the blastoderm embryo of the fruit fly Drosophila melanogaster. Based on this analysis, we propose a revised French Flag, which incorporates the dynamic, feedback-driven nature of pattern formation in the Drosophila blastoderm.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0265-9247
pubmed:author
pubmed:copyrightInfo
(c) 2006 Wiley Periodicals, Inc.
pubmed:issnType
Print
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1102-11
pubmed:dateRevised
2007-12-3
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
On the dynamic nature of positional information.
pubmed:affiliation
Laboratory of Development and Evolution, Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK. yoginho@gmail.com
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural