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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2006-12-22
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pubmed:abstractText |
Plasma apolipoprotein CIII (apoCIII) independently predicts risk for coronary heart disease (CHD). We recently reported that apoCIII directly enhances adhesion of human monocytes to endothelial cells (ECs), and identified the activation of PKC alpha as a necessary upstream event of enhanced monocyte adhesion. This study tested the hypothesis that apoCIII activates PKC alpha in human monocytic THP-1 cells, leading to NF-kappaB activation.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD29,
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoprotein C-III,
http://linkedlifedata.com/resource/pubmed/chemical/Bridged Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/GTP-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/Pertussis Toxin,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositol...,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphodiesterase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Thiones,
http://linkedlifedata.com/resource/pubmed/chemical/tricyclodecane-9-yl-xanthogenate
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1524-4636
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
219-25
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pubmed:dateRevised |
2011-10-13
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pubmed:meshHeading |
pubmed-meshheading:17038637-Antigens, CD29,
pubmed-meshheading:17038637-Apolipoprotein C-III,
pubmed-meshheading:17038637-Bridged Compounds,
pubmed-meshheading:17038637-Cell Adhesion,
pubmed-meshheading:17038637-Cell Line,
pubmed-meshheading:17038637-Endothelium, Vascular,
pubmed-meshheading:17038637-Enzyme Activation,
pubmed-meshheading:17038637-GTP-Binding Proteins,
pubmed-meshheading:17038637-Gene Expression Regulation,
pubmed-meshheading:17038637-Humans,
pubmed-meshheading:17038637-Monocytes,
pubmed-meshheading:17038637-NF-kappa B,
pubmed-meshheading:17038637-Pertussis Toxin,
pubmed-meshheading:17038637-Phosphatidylinositol Diacylglycerol-Lyase,
pubmed-meshheading:17038637-Phosphodiesterase Inhibitors,
pubmed-meshheading:17038637-Protein Kinase C-alpha,
pubmed-meshheading:17038637-Thiones
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pubmed:year |
2007
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pubmed:articleTitle |
Apolipoprotein CIII-induced THP-1 cell adhesion to endothelial cells involves pertussis toxin-sensitive G protein- and protein kinase C alpha-mediated nuclear factor-kappaB activation.
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pubmed:affiliation |
Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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