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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1991-2-25
|
| pubmed:abstractText |
IgG antibodies reactive with simian immunodeficiency virus isolated from a rhesus monkey suffering from simian acquired immunodeficiency syndrome (SIVmac, strain 239, a virus which is very closely related to human immunodeficiency virus type 2-HIV-2) were found in 18 of 120 Swedish and 8 of 11 east African confirmed HIV-1 antibody positive (HIV-1 ab+) sera, both by enzyme immunoassay and electrophoretic immunoblotting (p = 1 x 10(-6). In electrophoretic immunoblotting most of the cross-reactivity of SIVmac-reactive sera occurred on p27, the major gag protein of SIVmac. The possibility that SIVmac antibody reactivity could be due to double infection with HIV-1 and a SIVmac-related virus was eliminated by the results of absorptions between sera of Swedish and west and east African origin and viral antigens (SIVmac and North American or African/Haitian strains of HIV-1) coupled to agarose beads. HIV-2 ab+ and SIVmac reactive west African sera recognized SIVmac epitopes unrelated to HIV-1, whereas HIV-1 ab+, SIVmac reactive east African, and Swedish sera recognized SIVmac epitopes cross-reactive with epitopes present in both African and North American HIV-1 strains. No unique SIVmac-reactive African HIV-1 epitopes could thus be defined. Neither did absorption of Swedish and African HIV-1-positive sera with different HIV-1 strains (1 Haitian, 2 Zairian, and 1 North American) give evidence for unique epitopes.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes,
http://linkedlifedata.com/resource/pubmed/chemical/HIV Antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/HIV Antigens
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0300-5526
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
31
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
276-84
|
| pubmed:dateRevised |
2005-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:1703133-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:1703133-Animals,
pubmed-meshheading:1703133-Antibodies, Viral,
pubmed-meshheading:1703133-Antigens, Viral,
pubmed-meshheading:1703133-Cross Reactions,
pubmed-meshheading:1703133-Democratic Republic of the Congo,
pubmed-meshheading:1703133-Epitopes,
pubmed-meshheading:1703133-HIV Antibodies,
pubmed-meshheading:1703133-HIV Antigens,
pubmed-meshheading:1703133-HIV Seropositivity,
pubmed-meshheading:1703133-HIV-1,
pubmed-meshheading:1703133-HIV-2,
pubmed-meshheading:1703133-Humans,
pubmed-meshheading:1703133-Immunoenzyme Techniques,
pubmed-meshheading:1703133-Immunosorbent Techniques,
pubmed-meshheading:1703133-Macaca mulatta,
pubmed-meshheading:1703133-Simian immunodeficiency virus,
pubmed-meshheading:1703133-Sweden,
pubmed-meshheading:1703133-Uganda
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
Cross-reactivity with SIVmac in east African HIV-1-positive sera: evidence against double infection with HIV-1 and a SIVmac/HIV-2-like virus.
|
| pubmed:affiliation |
Department of Medical Microbiology, University of Lund, Sweden.
|
| pubmed:publicationType |
Journal Article
|