Linked Life Data

17030366

Source:http://linkedlifedata.com/resource/pubmed/id/17030366

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5-6
pubmed:dateCreated
2006-11-7
pubmed:abstractText
Microdomains of Ca(2+), which are formed at sites where Ca(2+) enters the cytoplasm either at the cell surface or at the internal stores, are a key element of Ca(2+) signalling. The term microdomain includes the elementary events that are the basic building blocks of Ca(2+) signals. As Ca(2+) enters the cytoplasm, it produces a local plume of Ca(2+) that has been given different names (sparks, puffs, sparklets and syntillas). These elementary events can combine to produce larger microdomains. The significance of these localized domains of Ca(2+) is that they can regulate specific cellular processes in different regions of the cell. Such microdomains are particularly evident in neurons where both pre- and postsynaptic events are controlled by highly localized pulses of Ca(2+). The ability of single neurons to process enormous amounts of information depends upon such miniaturization of the Ca(2+) signalling system. Control of cardiac cell contraction and gene transcription provides another example of how the parallel processing of Ca(2+) signalling can occur through microdomains of intracellular Ca(2+).
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0143-4160
pubmed:author
pubmed:issnType
Print
pubmed:volume
40
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
405-12
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:articleTitle
Calcium microdomains: organization and function.
pubmed:affiliation
Babraham Institute, Babraham, Cambridge, UK. michael.berridge@bbsrc.ac.uk
pubmed:publicationType
Journal Article, Review