Source:http://linkedlifedata.com/resource/pubmed/id/17027512
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
2006-10-9
|
| pubmed:abstractText |
Interleukin-22 (IL-22) is a cytokine that regulates the production of acute phase proteins of the immunological response. On binding to its cognate receptor (IL-22R1), which is associated to the interleukin-10 receptor 2 (IL-10R2), IL-22 promotes activation of signal transducer and activator of transcription (STAT) pathway and several other cellular responses. A soluble receptor termed interleukin-22 binding protein (IL-22BP) is also able to bind to IL-22 as a natural protein antagonist, and probably provides systemic regulation of IL-22 activity. This inflammatory response system is analyzed here in terms of its molecular physiology and structural assembly. Three-dimensional (3D) model of IL-22 and structural basis of its interactions with the cognate receptors are discussed.
|
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:issn |
0083-6729
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
74
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
77-103
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| pubmed:meshHeading |
pubmed-meshheading:17027512-Animals,
pubmed-meshheading:17027512-Cattle,
pubmed-meshheading:17027512-Crystallography, X-Ray,
pubmed-meshheading:17027512-Dogs,
pubmed-meshheading:17027512-Elephants,
pubmed-meshheading:17027512-Humans,
pubmed-meshheading:17027512-Inflammation,
pubmed-meshheading:17027512-Interleukins,
pubmed-meshheading:17027512-Macaca mulatta,
pubmed-meshheading:17027512-Mice,
pubmed-meshheading:17027512-Molecular Sequence Data,
pubmed-meshheading:17027512-Pan troglodytes,
pubmed-meshheading:17027512-Protein Binding,
pubmed-meshheading:17027512-Protein Conformation,
pubmed-meshheading:17027512-Rats,
pubmed-meshheading:17027512-Receptors, Interleukin,
pubmed-meshheading:17027512-Sequence Alignment,
pubmed-meshheading:17027512-Signal Transduction,
pubmed-meshheading:17027512-Swine
|
| pubmed:year |
2006
|
| pubmed:articleTitle |
Interleukin-22 and its crystal structure.
|
| pubmed:affiliation |
Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas Universidade Federal de Minas Gerais, Avenida Antônio Carlos, 6627 CEP 31270910, Belo Horizonte, MG, Brazil.
|
| pubmed:publicationType |
Journal Article,
Review
|