Linked Life Data

17023130

Source:http://linkedlifedata.com/resource/pubmed/id/17023130

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2007-1-15
pubmed:abstractText
This study presents the results of further investigations on the antinociceptive profiles of an aqueous seed extract of Aframomum melegueta in rodents. The antinociceptive activity of the intraperitonal doses of 25-100 mg/kg of Aframomum melegueta was assessed using the formalin-induced paw licking, Randall-Selitto paw pressure and hot plate models of pain. The extract was found to produce a significant dose-dependent inhibition of the inflammatory but not the neurogenic pains associated with the formalin test. In the Randall-Sellito paw pressure test, the extract significantly reduced the nociceptive responses elicited by compression of inflamed hind paw of rats in a dose-related manner. However, Aframomum melegueta did not alter the pain threshold in non-inflamed paw and also failed to prolong the reaction time of the animals to noxious heat in the hot plate test. Taken together, these findings suggest that the aqueous seed extract of Aframomum melegueta possess peripheral analgesic activity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0378-8741
pubmed:author
pubmed:issnType
Print
pubmed:day
12
pubmed:volume
109
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
501-4
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Further studies on the antinociceptive action of aqueous seed extract of Aframomum melegueta.
pubmed:affiliation
Department of Pharmacology and Therapeutics, University of Ibadan, Ibadan, Nigeria. umusolo@yahoo.com
pubmed:publicationType
Journal Article