Linked Life Data

17022948

Source:http://linkedlifedata.com/resource/pubmed/id/17022948

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2006-11-13
pubmed:abstractText
Curcuma longa is a major constituent of the traditional Chinese medicine Xiaoyao-san, which has been used to effectively manage stress and depression-related disorders in China. Curcumin is the active component of curcuma longa, and its antidepressant effects were described in our prior studies in mouse models of behavioral despair. We hypothesized that curcumin may also alleviate stress-induced depressive-like behaviors and hypothalamic-pituitary-adrenal (HPA) axis dysfunction. Thus in present study we assessed whether curcumin treatment (2.5, 5 and 10 mg/kg, p.o.) affects behavior in a chronic unpredictable stress model of depression in rats and examined what its molecular targets may be. We found that subjecting animals to the chronic stress protocol for 20days resulted in performance deficits in the shuttle-box task and several physiological effects, such as an abnormal adrenal gland weight to body weight (AG/B) ratio and increased thickness of the adrenal cortex as well as elevated serum corticosterone levels and reduced glucocorticoid receptor (GR) mRNA expression. These changes were reversed by chronic curcumin administration (5 or 10 mg/kg, p.o.). In addition, we also found that the chronic stress procedure induced a down-regulation of brain-derived neurotrophic factor (BDNF) protein levels and reduced the ratio of phosphorylated cAMP response element-binding protein (pCREB) to CREB levels (pCREB/CREB) in the hippocampus and frontal cortex of stressed rats. Furthermore, these stress-induced decreases in BDNF and pCREB/CREB were also blocked by chronic curcumin administration (5 or 10 mg/kg, p.o.). These results provide compelling evidence that the behavioral effects of curcumin in chronically stressed animals, and by extension humans, may be related to their modulating effects on the HPA axis and neurotrophin factor expressions.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
29
pubmed:volume
1122
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
56-64
pubmed:meshHeading
pubmed-meshheading:17022948-Adrenal Glands, pubmed-meshheading:17022948-Analysis of Variance, pubmed-meshheading:17022948-Animals, pubmed-meshheading:17022948-Body Weight, pubmed-meshheading:17022948-Brain-Derived Neurotrophic Factor, pubmed-meshheading:17022948-Corticosterone, pubmed-meshheading:17022948-Curcuma, pubmed-meshheading:17022948-Curcumin, pubmed-meshheading:17022948-Cyclic AMP Response Element-Binding Protein, pubmed-meshheading:17022948-Depressive Disorder, pubmed-meshheading:17022948-Dose-Response Relationship, Drug, pubmed-meshheading:17022948-Down-Regulation, pubmed-meshheading:17022948-Drugs, Chinese Herbal, pubmed-meshheading:17022948-Escape Reaction, pubmed-meshheading:17022948-Exploratory Behavior, pubmed-meshheading:17022948-Frontal Lobe, pubmed-meshheading:17022948-Hippocampus, pubmed-meshheading:17022948-Hypothalamo-Hypophyseal System, pubmed-meshheading:17022948-Male, pubmed-meshheading:17022948-Organ Size, pubmed-meshheading:17022948-Phosphorylation, pubmed-meshheading:17022948-Pituitary-Adrenal System, pubmed-meshheading:17022948-RNA, Messenger, pubmed-meshheading:17022948-Rats, pubmed-meshheading:17022948-Rats, Sprague-Dawley, pubmed-meshheading:17022948-Statistics, Nonparametric, pubmed-meshheading:17022948-Stress, Psychological
pubmed:year
2006
pubmed:articleTitle
Curcumin reverses the effects of chronic stress on behavior, the HPA axis, BDNF expression and phosphorylation of CREB.
pubmed:affiliation
Department of Pharmacology, School of Basic Medical Science, Peking University, 38 Xueyuan Road, Beijing, 100083, PR China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't