Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
19
pubmed:dateCreated
2006-10-5
pubmed:abstractText
We determined the effects of vorinostat [suberoylanilide hydroxamic acid (SAHA)] and/or dasatinib, a dual Abl/Src kinase (tyrosine kinase) inhibitor, on the cultured human (K562 and LAMA-84) or primary chronic myelogenous leukemia (CML) cells, as well as on the murine pro-B BaF3 cells with ectopic expression of the unmutated and kinase domain-mutant forms of Bcr-Abl.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Fusion Proteins, bcr-abl, http://linkedlifedata.com/resource/pubmed/chemical/Histone Deacetylase Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Hydroxamic Acids, http://linkedlifedata.com/resource/pubmed/chemical/Piperazines, http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Pyrimidines, http://linkedlifedata.com/resource/pubmed/chemical/STAT5 Transcription Factor, http://linkedlifedata.com/resource/pubmed/chemical/Thiazoles, http://linkedlifedata.com/resource/pubmed/chemical/dasatinib, http://linkedlifedata.com/resource/pubmed/chemical/imatinib, http://linkedlifedata.com/resource/pubmed/chemical/lyn protein-tyrosine kinase, http://linkedlifedata.com/resource/pubmed/chemical/src-Family Kinases, http://linkedlifedata.com/resource/pubmed/chemical/vorinostat
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1078-0432
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5869-78
pubmed:dateRevised
2011-11-2
pubmed:meshHeading
pubmed-meshheading:17020995-Animals, pubmed-meshheading:17020995-Antineoplastic Combined Chemotherapy Protocols, pubmed-meshheading:17020995-Apoptosis, pubmed-meshheading:17020995-Drug Resistance, Neoplasm, pubmed-meshheading:17020995-Drug Synergism, pubmed-meshheading:17020995-Fusion Proteins, bcr-abl, pubmed-meshheading:17020995-Histone Deacetylase Inhibitors, pubmed-meshheading:17020995-Humans, pubmed-meshheading:17020995-Hydroxamic Acids, pubmed-meshheading:17020995-K562 Cells, pubmed-meshheading:17020995-Leukemia, Myelogenous, Chronic, BCR-ABL Positive, pubmed-meshheading:17020995-Mice, pubmed-meshheading:17020995-Piperazines, pubmed-meshheading:17020995-Protein Kinase Inhibitors, pubmed-meshheading:17020995-Protein-Tyrosine Kinases, pubmed-meshheading:17020995-Pyrimidines, pubmed-meshheading:17020995-STAT5 Transcription Factor, pubmed-meshheading:17020995-Thiazoles, pubmed-meshheading:17020995-Tumor Cells, Cultured, pubmed-meshheading:17020995-src-Family Kinases
pubmed:year
2006
pubmed:articleTitle
Cotreatment with vorinostat (suberoylanilide hydroxamic acid) enhances activity of dasatinib (BMS-354825) against imatinib mesylate-sensitive or imatinib mesylate-resistant chronic myelogenous leukemia cells.
pubmed:affiliation
Department of Interdisciplinary Oncology, H. Lee Moffitt Cancer Center, University of South Florida, 12902 Magnolia Drive, Tampa, FL 33612, USA.
pubmed:publicationType
Journal Article