Linked Life Data

17018337

Source:http://linkedlifedata.com/resource/pubmed/id/17018337

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2006-10-4
pubmed:abstractText
Non-N-methyl-D-aspartate (non-NMDA) glutamate receptor antagonists modify multiple pain transmission pathways and are of particular interest in analgesic development because of their capacity to interfere with evoked pain. Evoked pain is a problem for postoperative patients and is characteristic of the plantar incision model for postoperative pain. The purpose of this study was to assess the efficacy of a non-NMDA receptor antagonist LY293558 on mechanical hyperalgesia after plantar incision in the rat. Parenteral, intrathecal, or intraplantar administration of LY293558 was tested against the mechanical hyperalgesia that characterizes the model. Sprague-Dawley rats were assigned to 1 of 3 groups. LY293558 or vehicle was administered intraperitoneally, intrathecally, or intraplantarly. The hind paw withdrawal threshold to punctate stimulation by using von Frey filaments and response frequency to a nonpunctate stimulus directly to the wound were measured. Motor tests after administration of LY293558 were also examined in rats that did not undergo incision. The greatest dose of parenterally administered LY293558 (34 micromol/kg) decreased the responses to mechanical stimuli after plantar incision. Rotorod performance was decreased at these same times. Intrathecal injection of LY293558 (0.5 and 2.0 nmol) produced inhibition of mechanical sensitivity and produced lower extremity motor side effects. Repeated intrathecal administration produced sustained anesthesia for 24 hours but had no analgesic effect the next day. Local administration did not decrease response after incision. LY293558 was most effective for evoked pain when administered intrathecally. PERSPECTIVE: Control of evoked pain after surgery is inadequate but is linked to perioperative outcome. These data suggest that non-NMDA receptor antagonists like LY293558 will be most effective for evoked pain in postoperative patients if administered spinally.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1526-5900
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
768-77
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:17018337-Afferent Pathways, pubmed-meshheading:17018337-Analgesics, pubmed-meshheading:17018337-Animals, pubmed-meshheading:17018337-Carboxylic Acids, pubmed-meshheading:17018337-Disease Models, Animal, pubmed-meshheading:17018337-Dose-Response Relationship, Drug, pubmed-meshheading:17018337-Drug Administration Routes, pubmed-meshheading:17018337-Excitatory Amino Acid Antagonists, pubmed-meshheading:17018337-Glutamic Acid, pubmed-meshheading:17018337-Hyperalgesia, pubmed-meshheading:17018337-Injections, Intraperitoneal, pubmed-meshheading:17018337-Injections, Spinal, pubmed-meshheading:17018337-Injections, Subcutaneous, pubmed-meshheading:17018337-Isoquinolines, pubmed-meshheading:17018337-Male, pubmed-meshheading:17018337-Nociceptors, pubmed-meshheading:17018337-Pain, Postoperative, pubmed-meshheading:17018337-Pain Measurement, pubmed-meshheading:17018337-Pain Threshold, pubmed-meshheading:17018337-Physical Stimulation, pubmed-meshheading:17018337-Rats, pubmed-meshheading:17018337-Rats, Sprague-Dawley, pubmed-meshheading:17018337-Receptors, AMPA, pubmed-meshheading:17018337-Tetrazoles, pubmed-meshheading:17018337-Treatment Outcome
pubmed:year
2006
pubmed:articleTitle
The effect of the AMPA/kainate receptor antagonist LY293558 in a rat model of postoperative pain.
pubmed:affiliation
Department of Anesthesia, University of Iowa, Iowa City, 52242-1079, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural