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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2006-10-26
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pubmed:abstractText |
We have previously reported the up-regulation of matrix metalloproteinase 10 (MMP-10) following treatment with the procatabolic stimulus of interleukin-1 (IL-1) and oncostatin M (OSM) in chondrocytes. Although MMP-10 is closely related to MMP-3, little is known about the role of MMP-10 in cartilage catabolism. The purpose of this study was to determine whether MMP-10 is expressed in connective tissue cells and to assess how it may contribute to cartilage collagenolysis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Collagen,
http://linkedlifedata.com/resource/pubmed/chemical/Collagenases,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Precursors,
http://linkedlifedata.com/resource/pubmed/chemical/Growth Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/MMP8 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 10,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 8,
http://linkedlifedata.com/resource/pubmed/chemical/Oncostatin M,
http://linkedlifedata.com/resource/pubmed/chemical/procollagenase
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0004-3591
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pubmed:author |
pubmed-author:BarksbyH EHE,
pubmed-author:CawstonT ETE,
pubmed-author:HufRR,
pubmed-author:LakeyRR,
pubmed-author:MiddletonJJ,
pubmed-author:MilnerJ MJM,
pubmed-author:PattersonA MAM,
pubmed-author:PeakeN JNJ,
pubmed-author:RichardsC DCD,
pubmed-author:RobsonTT,
pubmed-author:RowanA DAD
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pubmed:issnType |
Print
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pubmed:volume |
54
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3244-53
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pubmed:meshHeading |
pubmed-meshheading:17009259-Animals,
pubmed-meshheading:17009259-Arthritis,
pubmed-meshheading:17009259-Arthritis, Rheumatoid,
pubmed-meshheading:17009259-Cartilage,
pubmed-meshheading:17009259-Cattle,
pubmed-meshheading:17009259-Cells, Cultured,
pubmed-meshheading:17009259-Chondrocytes,
pubmed-meshheading:17009259-Collagen,
pubmed-meshheading:17009259-Collagenases,
pubmed-meshheading:17009259-Enzyme Precursors,
pubmed-meshheading:17009259-Fibroblasts,
pubmed-meshheading:17009259-Gene Expression Regulation,
pubmed-meshheading:17009259-Growth Inhibitors,
pubmed-meshheading:17009259-Humans,
pubmed-meshheading:17009259-Interleukin-1,
pubmed-meshheading:17009259-Matrix Metalloproteinase 1,
pubmed-meshheading:17009259-Matrix Metalloproteinase 10,
pubmed-meshheading:17009259-Matrix Metalloproteinase 8,
pubmed-meshheading:17009259-Mice,
pubmed-meshheading:17009259-Oncostatin M,
pubmed-meshheading:17009259-Osteoarthritis,
pubmed-meshheading:17009259-Synovial Membrane
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pubmed:year |
2006
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pubmed:articleTitle |
Matrix metalloproteinase 10 promotion of collagenolysis via procollagenase activation: implications for cartilage degradation in arthritis.
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pubmed:affiliation |
School of Clinical Medical Sciences, University of Newcastle, Newcastle-upon-Tyne, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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