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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
41
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pubmed:dateCreated |
2006-10-11
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pubmed:abstractText |
In comparison with CD4+ regulatory T cells, the generation and function of immunomodulatory CD8+T cells is less well defined. Here we describe the existence of regulatory anti-Kb-specific CD8+ T cells that are rendered tolerant during neonatal life via antigen contact exclusively on keratinocytes. These regulatory T cells maintain tolerance during adulthood as they prevent Kb-specific graft rejection by naïve CD8+ T cells. Third-party immune responses remain unaffected. Up-regulation of TGF-beta1 and granzyme B in the regulatory CD8+ T cell population suggests the involvement of these molecules in common suppressive pathways shared with CD4+ regulatory T cells. In summary, CD8+ regulatory T cells can be induced extrathymically through antigen contact on neonatally accessible parenchymal cells and maintain tolerance throughout adult life.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17008409-10037236,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17008409-10652468,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17008409-10888927,
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
10
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pubmed:volume |
103
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
15142-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:17008409-Animals,
pubmed-meshheading:17008409-Animals, Newborn,
pubmed-meshheading:17008409-Autoantigens,
pubmed-meshheading:17008409-CD8-Positive T-Lymphocytes,
pubmed-meshheading:17008409-Cell Differentiation,
pubmed-meshheading:17008409-Cell Line, Tumor,
pubmed-meshheading:17008409-Immune Tolerance,
pubmed-meshheading:17008409-Lymphocyte Activation,
pubmed-meshheading:17008409-Mice,
pubmed-meshheading:17008409-Mice, Knockout,
pubmed-meshheading:17008409-Mice, Transgenic,
pubmed-meshheading:17008409-T-Lymphocytes, Regulatory
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pubmed:year |
2006
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pubmed:articleTitle |
CD8+ regulatory T cells generated by neonatal recognition of peripheral self-antigen.
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pubmed:affiliation |
*Division of Molecular Immunology (D050), German Cancer Research Center, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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