Linked Life Data

17005853

Source:http://linkedlifedata.com/resource/pubmed/id/17005853

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
39
pubmed:dateCreated
2006-9-28
pubmed:abstractText
We assessed (1) whether the enantiomers of terpinen-4-ol, odorants that activate nearly identical areas of the olfactory bulb, are more difficult to discriminate than those of carvone, odorants that activate different areas of the olfactory bulb, and (2) whether olfactory bulb lesions that disrupt the pattern of bulbar activation produced by these enantiomers degraded the ability of rats to discriminate between them. In psychophysical tests, normal rats discriminated between the enantiomers of terpinen-4-ol and of carvone equally well. Surgical lesions that removed the majority of bulbar glomeruli activated by these odorants (as demonstrated in previous olfactory bulb studies using intrinsic optical imaging and 2-deoxyglucose) resulted in increased detection thresholds but few or no deficits in discriminating between suprathreshold concentrations of the enantiomers. These results fail to confirm predictions based on 2-deoxyglucose maps of bulbar activity that enantiomers of terpinen-4-ol should be more difficult to discriminate than those of carvone and that the ability to discriminate between enantiomers of an odorant are based on differences in patterns of bulbar activation revealed in such maps.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1529-2401
pubmed:author
pubmed:issnType
Electronic
pubmed:day
27
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
9892-901
pubmed:dateRevised
2007-12-3
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Discrimination between the enantiomers of carvone and of terpinen-4-ol odorants in normal rats and those with lesions of the olfactory bulbs.
pubmed:affiliation
Department of Psychology, American University, Washington, DC 20016, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, N.I.H., Extramural