| pubmed-article:16996647 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16996647 | lifeskim:mentions | umls-concept:C0003062 | lld:lifeskim |
| pubmed-article:16996647 | lifeskim:mentions | umls-concept:C0028754 | lld:lifeskim |
| pubmed-article:16996647 | lifeskim:mentions | umls-concept:C0066908 | lld:lifeskim |
| pubmed-article:16996647 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:16996647 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:16996647 | lifeskim:mentions | umls-concept:C0231204 | lld:lifeskim |
| pubmed-article:16996647 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:16996647 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:16996647 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:16996647 | pubmed:dateCreated | 2006-11-20 | lld:pubmed |
| pubmed-article:16996647 | pubmed:abstractText | Stimulation of mu opioid receptors preferentially increases the intake of a high fat diet. In this paper we investigated whether there was a difference in the expression of mu opioid receptors between animals susceptible (Osborne-Mendel) or resistant (S5B/Pl) to obesity induced by eating a high fat diet. Immunohistochemical studies demonstrated that Osborne-Mendel rats eating a chow diet had an increased number of mu opioid receptors in the arcuate nucleus when compared to S5B/Pl rats. These immunohistochemical findings were supported by Real Time-PCR which demonstrated that the mRNA level of mu opioid receptors was also increased in the hypothalamus of Osborne-Mendel rats compared to S5B/Pl rats. Low doses of the mu opioid receptor agonist DAMGO [d-Ala(2)-N-Me-Phe(4)-Glycol(5)]-enkephalin administered to Osborne-Mendel rats caused a significant increase in the preference for a diet high in fat. The same doses of DAMGO switched the diet preference of S5B/Pl rats to high fat but did not significantly increase food intake. The combination of these findings suggests that the increased levels of hypothalamic mu opioid receptors in Osborne-Mendel rats may contribute to their preference for a diet high in fat and increase their susceptibility to becoming obese. | lld:pubmed |
| pubmed-article:16996647 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16996647 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16996647 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16996647 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16996647 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16996647 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16996647 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16996647 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:16996647 | pubmed:issn | 0196-9781 | lld:pubmed |
| pubmed-article:16996647 | pubmed:author | pubmed-author:YorkDavid ADA | lld:pubmed |
| pubmed-article:16996647 | pubmed:author | pubmed-author:BrayGeorge... | lld:pubmed |
| pubmed-article:16996647 | pubmed:author | pubmed-author:HolmesGregory... | lld:pubmed |
| pubmed-article:16996647 | pubmed:author | pubmed-author:PrimeauxStefa... | lld:pubmed |
| pubmed-article:16996647 | pubmed:author | pubmed-author:BarnesMaria... | lld:pubmed |
| pubmed-article:16996647 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16996647 | pubmed:volume | 27 | lld:pubmed |
| pubmed-article:16996647 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16996647 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16996647 | pubmed:pagination | 3292-8 | lld:pubmed |
| pubmed-article:16996647 | pubmed:meshHeading | pubmed-meshheading:16996647... | lld:pubmed |
| pubmed-article:16996647 | pubmed:meshHeading | pubmed-meshheading:16996647... | lld:pubmed |
| pubmed-article:16996647 | pubmed:meshHeading | pubmed-meshheading:16996647... | lld:pubmed |
| pubmed-article:16996647 | pubmed:meshHeading | pubmed-meshheading:16996647... | lld:pubmed |
| pubmed-article:16996647 | pubmed:meshHeading | pubmed-meshheading:16996647... | lld:pubmed |
| pubmed-article:16996647 | pubmed:meshHeading | pubmed-meshheading:16996647... | lld:pubmed |
| pubmed-article:16996647 | pubmed:meshHeading | pubmed-meshheading:16996647... | lld:pubmed |
| pubmed-article:16996647 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16996647 | pubmed:articleTitle | Increased expression of mu opioid receptors in animals susceptible to diet-induced obesity. | lld:pubmed |
| pubmed-article:16996647 | pubmed:affiliation | Pennington Biomedical Research Center, Dietary Obesity Laboratory, Baton Rouge, LA 70808, USA. barnesmj@pbrc.edu | lld:pubmed |
| pubmed-article:16996647 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16996647 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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