Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6294
pubmed:dateCreated
1990-11-21
pubmed:abstractText
Mice carrying mutations at the W (Dominant white spotting) and Sl (Steel) loci develop abnormalities in three independent systems: neural crest-derived melanocytes, primordial germ cells and haematopoietic stem cells. Consequently, homozygotes of viable mutant alleles have white coats and are sterile and severely anaemic. Tissue recombination studies predict that the W gene is expressed cell autonomously, whereas the product of the Sl locus affects the microenvironment in which the stem cells migrate, proliferate and differentiate. The W locus encodes the protoncogene c-kit, a member of the tyrosine kinase receptor family. The haematopoietic growth factor SCF (stem cell factor) has been identified as the product of the Sl locus and a ligand for c-kit. Here, we report that SCF is expressed during embryogenesis in cells associated with both the migratory pathways and homing sites of melanoblasts, germ cells and haematopoietic stem cells. Both SCF and c-kit are also expressed in a variety of other tissues, including the brain and spinal cord, suggesting that the receptor-ligand system has additional roles in embryogenesis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0028-0836
pubmed:author
pubmed:issnType
Print
pubmed:day
18
pubmed:volume
347
pubmed:geneSymbol
Sl, c-kit
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
667-9
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:1699134-Animals, pubmed-meshheading:1699134-Bone and Bones, pubmed-meshheading:1699134-Brain, pubmed-meshheading:1699134-Embryo, Mammalian, pubmed-meshheading:1699134-Gene Expression, pubmed-meshheading:1699134-Germ Cells, pubmed-meshheading:1699134-Hematopoietic Cell Growth Factors, pubmed-meshheading:1699134-Hematopoietic Stem Cells, pubmed-meshheading:1699134-Liver, pubmed-meshheading:1699134-Melanocytes, pubmed-meshheading:1699134-Mice, pubmed-meshheading:1699134-Mice, Mutant Strains, pubmed-meshheading:1699134-Nucleic Acid Hybridization, pubmed-meshheading:1699134-Proto-Oncogene Proteins, pubmed-meshheading:1699134-Proto-Oncogene Proteins c-kit, pubmed-meshheading:1699134-RNA, pubmed-meshheading:1699134-Spinal Cord, pubmed-meshheading:1699134-Tissue Distribution, pubmed-meshheading:1699134-Yolk Sac
pubmed:year
1990
pubmed:articleTitle
Embryonic expression of a haematopoietic growth factor encoded by the Sl locus and the ligand for c-kit.
pubmed:affiliation
Department of Cell Biology, Vanderbilt University Medical School, Nashville, Tennessee 37232-2172.
pubmed:publicationType
Journal Article