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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6294
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pubmed:dateCreated |
1990-11-21
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pubmed:abstractText |
Mice carrying mutations at the W (Dominant white spotting) and Sl (Steel) loci develop abnormalities in three independent systems: neural crest-derived melanocytes, primordial germ cells and haematopoietic stem cells. Consequently, homozygotes of viable mutant alleles have white coats and are sterile and severely anaemic. Tissue recombination studies predict that the W gene is expressed cell autonomously, whereas the product of the Sl locus affects the microenvironment in which the stem cells migrate, proliferate and differentiate. The W locus encodes the protoncogene c-kit, a member of the tyrosine kinase receptor family. The haematopoietic growth factor SCF (stem cell factor) has been identified as the product of the Sl locus and a ligand for c-kit. Here, we report that SCF is expressed during embryogenesis in cells associated with both the migratory pathways and homing sites of melanoblasts, germ cells and haematopoietic stem cells. Both SCF and c-kit are also expressed in a variety of other tissues, including the brain and spinal cord, suggesting that the receptor-ligand system has additional roles in embryogenesis.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0028-0836
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
18
|
pubmed:volume |
347
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pubmed:geneSymbol |
Sl,
c-kit
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pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
667-9
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:1699134-Animals,
pubmed-meshheading:1699134-Bone and Bones,
pubmed-meshheading:1699134-Brain,
pubmed-meshheading:1699134-Embryo, Mammalian,
pubmed-meshheading:1699134-Gene Expression,
pubmed-meshheading:1699134-Germ Cells,
pubmed-meshheading:1699134-Hematopoietic Cell Growth Factors,
pubmed-meshheading:1699134-Hematopoietic Stem Cells,
pubmed-meshheading:1699134-Liver,
pubmed-meshheading:1699134-Melanocytes,
pubmed-meshheading:1699134-Mice,
pubmed-meshheading:1699134-Mice, Mutant Strains,
pubmed-meshheading:1699134-Nucleic Acid Hybridization,
pubmed-meshheading:1699134-Proto-Oncogene Proteins,
pubmed-meshheading:1699134-Proto-Oncogene Proteins c-kit,
pubmed-meshheading:1699134-RNA,
pubmed-meshheading:1699134-Spinal Cord,
pubmed-meshheading:1699134-Tissue Distribution,
pubmed-meshheading:1699134-Yolk Sac
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pubmed:year |
1990
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pubmed:articleTitle |
Embryonic expression of a haematopoietic growth factor encoded by the Sl locus and the ligand for c-kit.
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pubmed:affiliation |
Department of Cell Biology, Vanderbilt University Medical School, Nashville, Tennessee 37232-2172.
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pubmed:publicationType |
Journal Article
|