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16990386
Source:
http://linkedlifedata.com/resource/pubmed/id/16990386
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Predicate
Object
rdf:type
pubmed:Citation
lifeskim:mentions
umls-concept:C0009543
,
umls-concept:C0024790
,
umls-concept:C1541483
pubmed:issue
12
pubmed:dateCreated
2006-9-22
pubmed:databankReference
http://linkedlifedata.com/resource/pubmed/xref/ClinicalTrials.gov/NCT00122330
pubmed:abstractText
We tested the safety and efficacy of eculizumab, a humanized monoclonal antibody against terminal complement protein C5 that inhibits terminal complement activation, in patients with paroxysmal nocturnal hemoglobinuria (PNH).
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/16990386-17192547
,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16990386-17193722
,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16990386-17195305
,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16990386-17195307
pubmed:language
eng
pubmed:journal
http://linkedlifedata.com/resource/pubmed/journal/0255562
pubmed:citationSubset
AIM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal
,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal, Humanized
,
http://linkedlifedata.com/resource/pubmed/chemical/Complement C5
,
http://linkedlifedata.com/resource/pubmed/chemical/Hemoglobins
,
http://linkedlifedata.com/resource/pubmed/chemical/eculizumab
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1533-4406
pubmed:author
pubmed-author:BrodskyRobert ARA
,
pubmed-author:BrownePaulP
,
pubmed-author:ElebuteModupe OMO
,
pubmed-author:FuChieh-LinCL
,
pubmed-author:HillAnitaA
,
pubmed-author:HillmenPeterP
,
pubmed-author:LuzzattoLucioL
,
pubmed-author:MaciejewskiJaroslawJ
,
pubmed-author:MojcikChristopher FCF
,
pubmed-author:MuusPetraP
,
pubmed-author:NakamuraRyotaroR
,
pubmed-author:RöthAlexanderA
,
pubmed-author:RisitanoAntonio MAM
,
pubmed-author:RollinsScott ASA
,
pubmed-author:RotherRussell PRP
,
pubmed-author:SchrezenmeierHubertH
,
pubmed-author:SchubertJörgJ
,
pubmed-author:SociéGerardG
,
pubmed-author:SzerJeffreyJ
,
pubmed-author:YoungNeal SNS
pubmed:copyrightInfo
2006 Massachusetts Medical Society
pubmed:issnType
Electronic
pubmed:day
21
pubmed:volume
355
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1233-43
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:16990386-Adolescent
,
pubmed-meshheading:16990386-Adult
,
pubmed-meshheading:16990386-Aged
,
pubmed-meshheading:16990386-Aged, 80 and over
,
pubmed-meshheading:16990386-Antibodies, Monoclonal
,
pubmed-meshheading:16990386-Antibodies, Monoclonal, Humanized
,
pubmed-meshheading:16990386-Complement C5
,
pubmed-meshheading:16990386-Double-Blind Method
,
pubmed-meshheading:16990386-Erythrocyte Transfusion
,
pubmed-meshheading:16990386-Fatigue
,
pubmed-meshheading:16990386-Female
,
pubmed-meshheading:16990386-Hemoglobins
,
pubmed-meshheading:16990386-Hemoglobinuria, Paroxysmal
,
pubmed-meshheading:16990386-Hemolysis
,
pubmed-meshheading:16990386-Humans
,
pubmed-meshheading:16990386-Male
,
pubmed-meshheading:16990386-Middle Aged
,
pubmed-meshheading:16990386-Quality of Life
pubmed:year
2006
pubmed:articleTitle
The complement inhibitor eculizumab in paroxysmal nocturnal hemoglobinuria.
pubmed:affiliation
Leeds General Infirmary, Leeds, United Kingdom. peter.hillmen@nhs.net
pubmed:publicationType
Journal Article
,
Randomized Controlled Trial
,
Research Support, Non-U.S. Gov't
,
Multicenter Study
,
Clinical Trial, Phase III