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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2006-9-22
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pubmed:abstractText |
The multidrug resistance (MDR1) gene encodes for P-glycoprotein, a drug efflux pump. Mice deficient for the MDR1a gene spontaneously develop colitis. In humans, a polymorphism in exon 26 (C3435T) is associated with reduced expression levels and function of MDR1. Currently there are controversial data on the association between MDR1 and inflammatory bowel disease (IBD). The purpose of this study was to examine the involvement of this gene in IBD in a large population of Dutch patients with IBD and family-based controls.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0036-5521
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pubmed:author |
pubmed-author:DijkstraGerardG,
pubmed-author:FaberKlaas NKN,
pubmed-author:JansenPeter L MPL,
pubmed-author:KleibeukerJan HJH,
pubmed-author:NolteIlja MIM,
pubmed-author:OostenbrugLiekele ELE,
pubmed-author:OosteromElviraE,
pubmed-author:de JongDirk JDJ,
pubmed-author:te MeermanGerard JGJ,
pubmed-author:van DullemenHendrik MHM,
pubmed-author:van der LindeKlaasK,
pubmed-author:van der SteegeGerritG
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pubmed:issnType |
Print
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pubmed:volume |
41
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1174-82
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pubmed:meshHeading |
pubmed-meshheading:16990202-Adult,
pubmed-meshheading:16990202-Colitis, Ulcerative,
pubmed-meshheading:16990202-Crohn Disease,
pubmed-meshheading:16990202-Drug Resistance, Multiple,
pubmed-meshheading:16990202-Female,
pubmed-meshheading:16990202-Genotype,
pubmed-meshheading:16990202-Humans,
pubmed-meshheading:16990202-Inflammatory Bowel Diseases,
pubmed-meshheading:16990202-Male,
pubmed-meshheading:16990202-Microsatellite Repeats,
pubmed-meshheading:16990202-P-Glycoprotein,
pubmed-meshheading:16990202-Phenotype,
pubmed-meshheading:16990202-Polymorphism, Single Nucleotide
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pubmed:year |
2006
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pubmed:articleTitle |
Absence of association between the multidrug resistance (MDR1) gene and inflammatory bowel disease.
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pubmed:affiliation |
Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, The Netherlands. l.e.oostenbrug@inter.nl.net
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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