Source:http://linkedlifedata.com/resource/pubmed/id/16986955
Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
20
|
pubmed:dateCreated |
2006-9-21
|
pubmed:abstractText |
The design, asymmetric synthesis, and biological evaluation of a new class of bryostatin analogues based on a pseudosymmetric spacer domain are described. An aryl bromide diversification site is incorporated allowing access to systematically varied analogues. The new analogues all exhibit potent, nanomolar affinity to PKC.
|
pubmed:grant | |
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Bryostatins,
http://linkedlifedata.com/resource/pubmed/chemical/Hydrogen,
http://linkedlifedata.com/resource/pubmed/chemical/Macrolides,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C,
http://linkedlifedata.com/resource/pubmed/chemical/bryostatin 1
|
pubmed:status |
MEDLINE
|
pubmed:month |
Sep
|
pubmed:issn |
1523-7060
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
28
|
pubmed:volume |
8
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
4581-4
|
pubmed:dateRevised |
2007-11-15
|
pubmed:meshHeading | |
pubmed:year |
2006
|
pubmed:articleTitle |
Synthesis and PKC binding of a new class of a-ring diversifiable bryostatin analogues utilizing a double asymmetric hydrogenation and cross-coupling strategy.
|
pubmed:affiliation |
Department of Chemistry, Stanford University, Stanford, California 94305-5080, USA. wenderp@stanford.edu
|
pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
|