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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
19
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pubmed:dateCreated |
2006-9-14
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pubmed:abstractText |
Pyrrolo[1,2-b][1,2,5]benzothiadiazepine 5,5-dioxides (PBTDs) induced apoptosis in human BCR-ABL-expressing leukemia cells. The apoptotic activity was also observed in primary leukemic blasts, obtained from chronic myelogenous leukemia (CML) patients at onset or from patients in blast crisis and who were imatinib-resistant. Compounds 5 and 14 induced apoptosis before BCR-ABL protein expression and tyrosin phosphorylation were affected and activated different caspases in the apoptotic pathway. PBTDs are a new class of valid candidates for the treatment of CML.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Bcr-Abl tyrosine kinase,
http://linkedlifedata.com/resource/pubmed/chemical/CASP3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CASP8 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CASP9 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 8,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 9,
http://linkedlifedata.com/resource/pubmed/chemical/Caspases,
http://linkedlifedata.com/resource/pubmed/chemical/Fusion Proteins, bcr-abl,
http://linkedlifedata.com/resource/pubmed/chemical/Piperazines,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrimidines,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrroles,
http://linkedlifedata.com/resource/pubmed/chemical/Thiazepines,
http://linkedlifedata.com/resource/pubmed/chemical/imatinib
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0022-2623
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pubmed:author |
pubmed-author:AbruzzeseElisabettaE,
pubmed-author:AmadoriSergioS,
pubmed-author:ArticoMarinoM,
pubmed-author:CatalanoGianfrancoG,
pubmed-author:CirilliRobertoR,
pubmed-author:CirioloMaria RosaMR,
pubmed-author:Di StefanoCarlaC,
pubmed-author:FilomeniGiuseppeG,
pubmed-author:La ReginaGiuseppeG,
pubmed-author:La TorreFrancescoF,
pubmed-author:LavecchiaAntonioA,
pubmed-author:MarfèGabriellaG,
pubmed-author:MorganteEmanuelaE,
pubmed-author:MorganteManuelaM,
pubmed-author:NovellinoEttoreE,
pubmed-author:RussoMatteo AntonioMA,
pubmed-author:SilvestriRomanoR,
pubmed-author:Sinibaldi SalimeiPaolaP
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pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
49
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5840-4
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16970408-Antineoplastic Agents,
pubmed-meshheading:16970408-Apoptosis,
pubmed-meshheading:16970408-Bone Marrow Cells,
pubmed-meshheading:16970408-Caspase 3,
pubmed-meshheading:16970408-Caspase 8,
pubmed-meshheading:16970408-Caspase 9,
pubmed-meshheading:16970408-Caspases,
pubmed-meshheading:16970408-Drug Resistance, Neoplasm,
pubmed-meshheading:16970408-Enzyme Activation,
pubmed-meshheading:16970408-Fusion Proteins, bcr-abl,
pubmed-meshheading:16970408-Humans,
pubmed-meshheading:16970408-K562 Cells,
pubmed-meshheading:16970408-Leukemia, Myelogenous, Chronic, BCR-ABL Positive,
pubmed-meshheading:16970408-Piperazines,
pubmed-meshheading:16970408-Protein-Tyrosine Kinases,
pubmed-meshheading:16970408-Pyrimidines,
pubmed-meshheading:16970408-Pyrroles,
pubmed-meshheading:16970408-Thiazepines,
pubmed-meshheading:16970408-Tumor Cells, Cultured
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pubmed:year |
2006
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pubmed:articleTitle |
Pyrrolo[1,2-b][1,2,5]benzothiadiazepines (PBTDs): A new class of agents with high apoptotic activity in chronic myelogenous leukemia K562 cells and in cells from patients at onset and who were imatinib-resistant.
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pubmed:affiliation |
Dipartimento di Studi Farmaceutici, Università La Sapienza, Piazzale Aldo Moro 5, I-00185 Roma, Italy. romano.silvestri@uniroma1.it
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pubmed:publicationType |
Journal Article
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