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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1990-9-27
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pubmed:abstractText |
T cell lines specific for measles virus (MV) were generated from blood of two DR1/DR2 heterozygous healthy donors with a history of past measles infection. The antigenic specificity of 66 T cell clones derived from the lines was studied in a blastogenic assay using whole measles virus and two purified virus components, haemagglutinin and nucleocapsid. Thirty-nine of the clones were specific for one of the two purified antigens. None of the seven synthetic peptides covering 20% of the MV haemagglutinin amino acid sequence stimulated T cell clones with haemagglutinin specificity. Responsiveness of the majority of the clones were restricted by HLA-D/DR antigens, although two clones were isolated that responded only to MV antigens presented by autologous cells. Ten of 11 clones recognizing the nucleocapsid antigen were DR1-restricted, while the haemagglutinin antigen and whole measles virions were recognized more often in association with the DR2 antigen. These results indicate that much of the MV-specific memory T cell response is specific for the haemagglutinin and nucleocapsid virus antigens, with the DR antigen being the main restriction element involved.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1696862-126271,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1696862-220840,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1696862-2428863,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1696862-2430611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1696862-2435793,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1696862-2467943,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1696862-2578511,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1696862-2786244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1696862-2838584,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1696862-2982912,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1696862-3008420,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1696862-3042616,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1696862-315204,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1696862-3280184,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1696862-3509946,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1696862-4033727,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1696862-4135465,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1696862-4291924,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1696862-6203977,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1696862-6598011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1696862-6601275,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1696862-6699941,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1696862-6966188,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1696862-726895
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0009-9104
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
81
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
212-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1696862-Adult,
pubmed-meshheading:1696862-Antibodies, Monoclonal,
pubmed-meshheading:1696862-Antigens, Viral,
pubmed-meshheading:1696862-Capsid,
pubmed-meshheading:1696862-Clone Cells,
pubmed-meshheading:1696862-Epitopes,
pubmed-meshheading:1696862-HLA Antigens,
pubmed-meshheading:1696862-Hemagglutinins, Viral,
pubmed-meshheading:1696862-Humans,
pubmed-meshheading:1696862-Lymphocyte Activation,
pubmed-meshheading:1696862-Male,
pubmed-meshheading:1696862-Measles,
pubmed-meshheading:1696862-Measles virus,
pubmed-meshheading:1696862-Phenotype,
pubmed-meshheading:1696862-T-Lymphocytes,
pubmed-meshheading:1696862-Viral Core Proteins
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pubmed:year |
1990
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pubmed:articleTitle |
Cloning of human T cells specific for measles virus haemagglutinin and nucleocapsid.
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pubmed:affiliation |
Department of Medical Microbiology, University of Oulu, Finland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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