16962236

Source:http://linkedlifedata.com/resource/pubmed/id/16962236

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0010531, umls-concept:C0019564, umls-concept:C0039062, umls-concept:C0205341, umls-concept:C0679133, umls-concept:C1413038, umls-concept:C1627358, umls-concept:C1879547, umls-concept:C2348519, umls-concept:C2349975
pubmed:issue	1
pubmed:dateCreated	2006-9-18
pubmed:abstractText	We reported previously that repeated activations, but not a single activation, of cyclic AMP-dependent protein kinase (PKA), led to a slowly developing (requiring approximately 1 week to develop) long-lasting (lasting > or = 3 weeks) enhancement of synaptic transmission efficiency in the organotypic slice culture of the rat hippocampus. It was accompanied by an increase in the number of synapses identified immunohistochemically. To answer the question of whether the "perforated synapse", which is known to occur transiently after the induction of long-term potentiation (LTP) in combination with the enlargement of postsynaptic density (PSD), is involved also in this slow/persistent synaptic enhancement, we examined the ultrastructural changes after the repeated activations of PKA. The answer was partially yes (occurrence of perforated synapses was increased) but partially no (the increase in the number of perforated synapses was not transient but persistent; mean apparent size of PSD did not increase). These results suggest that the mechanism of the slow/persistent synaptogenesis shares limited features with the mechanism of the quick/transient morphogenesis after LTP.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/7600130
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP-Dependent Protein Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Forskolin
pubmed:status	MEDLINE
pubmed:month	Oct
pubmed:issn	0304-3940
pubmed:author	pubmed-author:OguraAkihikoA, pubmed-author:Tominaga-YoshinoKeikoK, pubmed-author:UrakuboTomoyoshiT
pubmed:issnType	Print
pubmed:day	16
pubmed:volume	407
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	1-5
pubmed:dateRevised	2007-11-15
pubmed:meshHeading	pubmed-meshheading:16962236-Animals, pubmed-meshheading:16962236-Animals, Newborn, pubmed-meshheading:16962236-Cyclic AMP-Dependent Protein Kinases, pubmed-meshheading:16962236-Dendrites, pubmed-meshheading:16962236-Drug Administration Schedule, pubmed-meshheading:16962236-Enzyme Activation, pubmed-meshheading:16962236-Excitatory Postsynaptic Potentials, pubmed-meshheading:16962236-Forskolin, pubmed-meshheading:16962236-Hippocampus, pubmed-meshheading:16962236-Long-Term Potentiation, pubmed-meshheading:16962236-Microscopy, Electron, Transmission, pubmed-meshheading:16962236-Organ Culture Techniques, pubmed-meshheading:16962236-Rats, pubmed-meshheading:16962236-Rats, Wistar, pubmed-meshheading:16962236-Synapses, pubmed-meshheading:16962236-Synaptic Transmission, pubmed-meshheading:16962236-Time Factors
pubmed:year	2006
pubmed:articleTitle	Ultrastructural features of hippocampal CA1 synapses with respect to synaptic enhancement following repeated PKA activation.
pubmed:affiliation	Department of Biology, Osaka University Graduate School of Science, Toyonaka, Osaka 560-0043, Japan.
pubmed:publicationType	Journal Article, Comparative Study, In Vitro, Research Support, Non-U.S. Gov't