Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2007-1-8
pubmed:abstractText
Exogenous administration of orexin can promote wakefulness and respiration. Here we examined whether intrinsic orexin participates in the control of breathing in a vigilance state-dependent manner. Ventilation was recorded together with electroencephalography and electromyography for 6 h during the daytime in prepro-orexin knockout mice (ORX-KO) and wild-type (WT) littermates. Respiratory parameters were separately determined during quiet wakefulness (QW), slow-wave sleep (SWS), or rapid eye movement (REM) sleep. Basal ventilation was normal in ORX-KO, irrespective of vigilance states. The hypercapnic ventilatory response during QW in ORX-KO (0.19 +/- 0.01 ml.min(-1).g(-1).%CO(2)(-1)) was significantly smaller than that in WT mice (0.38 +/- 0.04 ml.min(-1).g(-1).%CO(2)(-1)), whereas the responses during SWS and REM in ORX-KO were comparable to those in WT mice. Hypoxic responses during wake and sleep periods were not different between the genotypes. Spontaneous but not postsigh sleep apneas were more frequent in ORX-KO than in WT littermates during both SWS and REM sleep. Our findings suggest that orexin plays a crucial role both in CO(2) sensitivity during wakefulness and in preserving ventilation stability during sleep.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
8750-7587
pubmed:author
pubmed:issnType
Print
pubmed:volume
102
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
241-8
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:16959906-Animals, pubmed-meshheading:16959906-Anoxia, pubmed-meshheading:16959906-Arousal, pubmed-meshheading:16959906-Chemoreceptor Cells, pubmed-meshheading:16959906-Electroencephalography, pubmed-meshheading:16959906-Electromyography, pubmed-meshheading:16959906-Gene Expression Regulation, pubmed-meshheading:16959906-Hypercapnia, pubmed-meshheading:16959906-Intracellular Signaling Peptides and Proteins, pubmed-meshheading:16959906-Male, pubmed-meshheading:16959906-Mice, pubmed-meshheading:16959906-Mice, Knockout, pubmed-meshheading:16959906-Neuropeptides, pubmed-meshheading:16959906-Pulmonary Ventilation, pubmed-meshheading:16959906-Respiratory Physiological Phenomena, pubmed-meshheading:16959906-Respiratory System, pubmed-meshheading:16959906-Sleep, pubmed-meshheading:16959906-Sleep, REM, pubmed-meshheading:16959906-Sleep Apnea Syndromes, pubmed-meshheading:16959906-Time Factors, pubmed-meshheading:16959906-Wakefulness
pubmed:year
2007
pubmed:articleTitle
Vigilance state-dependent attenuation of hypercapnic chemoreflex and exaggerated sleep apnea in orexin knockout mice.
pubmed:affiliation
Department of Autonomic Physiology, Chiba University Graduate School of Medicine, Chiba-city, Chiba, Japan.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't