| pubmed-article:16959375 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16959375 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:16959375 | lifeskim:mentions | umls-concept:C0025201 | lld:lifeskim |
| pubmed-article:16959375 | lifeskim:mentions | umls-concept:C0010132 | lld:lifeskim |
| pubmed-article:16959375 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:16959375 | lifeskim:mentions | umls-concept:C0079904 | lld:lifeskim |
| pubmed-article:16959375 | lifeskim:mentions | umls-concept:C1366488 | lld:lifeskim |
| pubmed-article:16959375 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:16959375 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:16959375 | pubmed:dateCreated | 2006-11-20 | lld:pubmed |
| pubmed-article:16959375 | pubmed:abstractText | Corticotropin releasing hormone (CRH), a messenger of stress at the central level, is expressed in the epidermis where it operates within local equivalent of hypothalamo-pituitary axis. CRH inhibits NF-kappaB activity in human immortalized epidermal (PIG1) melanocytes. In melanocytes CRH stimulates pro-opiomelanocortin (POMC) mRNA and adrenocorticotropin (ACTH) peptide production. Knockdown of POMC levels by transfecting cells with antisense oligonucleotides blocks the effect of CRH on NF-kappaB signaling indicating that the above inhibition is indirect, e.g. through activation of POMC. We suggest that induction of POMC by CRH serves as a feedback mechanism to self-restrict inflammatory response in the skin. | lld:pubmed |
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| pubmed-article:16959375 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:16959375 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16959375 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16959375 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:16959375 | pubmed:issn | 0196-9781 | lld:pubmed |
| pubmed-article:16959375 | pubmed:author | pubmed-author:ZbytekBlazejB | lld:pubmed |
| pubmed-article:16959375 | pubmed:author | pubmed-author:SlominskiAndr... | lld:pubmed |
| pubmed-article:16959375 | pubmed:author | pubmed-author:PfefferLawren... | lld:pubmed |
| pubmed-article:16959375 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16959375 | pubmed:volume | 27 | lld:pubmed |
| pubmed-article:16959375 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16959375 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16959375 | pubmed:pagination | 3276-83 | lld:pubmed |
| pubmed-article:16959375 | pubmed:dateRevised | 2011-9-26 | lld:pubmed |
| pubmed-article:16959375 | pubmed:meshHeading | pubmed-meshheading:16959375... | lld:pubmed |
| pubmed-article:16959375 | pubmed:meshHeading | pubmed-meshheading:16959375... | lld:pubmed |
| pubmed-article:16959375 | pubmed:meshHeading | pubmed-meshheading:16959375... | lld:pubmed |
| pubmed-article:16959375 | pubmed:meshHeading | pubmed-meshheading:16959375... | lld:pubmed |
| pubmed-article:16959375 | pubmed:meshHeading | pubmed-meshheading:16959375... | lld:pubmed |
| pubmed-article:16959375 | pubmed:meshHeading | pubmed-meshheading:16959375... | lld:pubmed |
| pubmed-article:16959375 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16959375 | pubmed:articleTitle | CRH inhibits NF-kappa B signaling in human melanocytes. | lld:pubmed |
| pubmed-article:16959375 | pubmed:affiliation | Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, 930 Madison Avenue #525, Memphis, TN 38163, USA. | lld:pubmed |
| pubmed-article:16959375 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16959375 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16959375 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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