|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
12
|
|
pubmed:dateCreated |
2006-11-20
|
|
pubmed:abstractText |
Corticotropin releasing hormone (CRH), a messenger of stress at the central level, is expressed in the epidermis where it operates within local equivalent of hypothalamo-pituitary axis. CRH inhibits NF-kappaB activity in human immortalized epidermal (PIG1) melanocytes. In melanocytes CRH stimulates pro-opiomelanocortin (POMC) mRNA and adrenocorticotropin (ACTH) peptide production. Knockdown of POMC levels by transfecting cells with antisense oligonucleotides blocks the effect of CRH on NF-kappaB signaling indicating that the above inhibition is indirect, e.g. through activation of POMC. We suggest that induction of POMC by CRH serves as a feedback mechanism to self-restrict inflammatory response in the skin.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16959375-10433314,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16959375-10504441,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16959375-10628754,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16959375-10821844,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16959375-10893429,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16959375-11095741,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16959375-11150642,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16959375-11160941,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16959375-11429644,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16959375-11481215,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16959375-11790788,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16959375-11860150,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16959375-12360211,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16959375-12403845,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16959375-12485424,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16959375-12816950,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16959375-12933679,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16959375-14605004,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16959375-14675201,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16959375-14711817,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16959375-14724292,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16959375-15122352,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16959375-15171702,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16959375-15281340,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16959375-15383650,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16959375-15464079,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16959375-15468147,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16959375-15491778,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16959375-15833364,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16959375-16245303,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16959375-16332989,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16959375-16720310,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16959375-1731761,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16959375-2836187,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16959375-6267699,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16959375-7577707,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16959375-7588301,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16959375-7597287,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16959375-7715646,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16959375-7739549,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16959375-8980146,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16959375-9057089,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16959375-9388244
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
0196-9781
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
27
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
3276-83
|
|
pubmed:dateRevised |
2011-9-26
|
|
pubmed:meshHeading |
|
|
pubmed:year |
2006
|
|
pubmed:articleTitle |
CRH inhibits NF-kappa B signaling in human melanocytes.
|
|
pubmed:affiliation |
Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, 930 Madison Avenue #525, Memphis, TN 38163, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|
