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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2006-9-25
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pubmed:abstractText |
Antinuclear antibodies are useful diagnostic tools in several autoimmune diseases. However, the routine detection of nuclear envelope autoantibodies using immunofluorescence (IF) is not always easy to perform in patients' sera because of the presence of autoantibodies to other nuclear and cytoplasmic components which could mask the characteristic rim-like pattern of nuclear envelope autoantibodies. This is particularly common in sera from patients with primary biliary cirrhosis (PBC), which generaly have high titres of anti-mitochondrial antibodies. Therefore, we have assayed a number of commercial slides and alternative fixation conditions to optimize the detection of anti-nuclear envelope antibodies (ANEA) in PBC sera.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16956395-10651254,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16956395-11322196,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16956395-11481607,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16956395-12753810,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16956395-12848948,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16956395-14594130,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16956395-15086405,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16956395-15753539,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16956395-2188869,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16956395-2195063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16956395-2716784,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16956395-3308206,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16956395-7631159,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16956395-8608894,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16956395-8878441,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16956395-9112233,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16956395-9378763,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16956395-986398
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2172
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
20
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16956395-Adult,
pubmed-meshheading:16956395-Aged,
pubmed-meshheading:16956395-Antibodies, Antinuclear,
pubmed-meshheading:16956395-Cell Line, Tumor,
pubmed-meshheading:16956395-Female,
pubmed-meshheading:16956395-Fixatives,
pubmed-meshheading:16956395-Fluorescent Antibody Technique, Indirect,
pubmed-meshheading:16956395-Formaldehyde,
pubmed-meshheading:16956395-HeLa Cells,
pubmed-meshheading:16956395-Humans,
pubmed-meshheading:16956395-Male,
pubmed-meshheading:16956395-Microscopy, Fluorescence,
pubmed-meshheading:16956395-Middle Aged,
pubmed-meshheading:16956395-Nuclear Envelope
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pubmed:year |
2006
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pubmed:articleTitle |
Optimized detection of circulating anti-nuclear envelope autoantibodies by immunofluorescence.
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pubmed:affiliation |
Biochemistry, University of Crete, School of Medicine, P,O, Box 2208, Heraklion 71003, Greece. bio1020@edu.biology.uoc.gr
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Evaluation Studies
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