Linked Life Data

1693501

Source:http://linkedlifedata.com/resource/pubmed/id/1693501

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1990-7-11
pubmed:abstractText
Intracisternal A-particles (IAP) genes in variable copy number exist in all rodent species studied. Expression is highly repressed in murine normal cells except in embryonic and transformed cells. We searched for IAP related sequences expression in another rodent species cells. Using the more conserved sequence of IAP gene between mouse, Syrian hamster, and rat species (0.4 kb HindIII-PstI fragment from PMIA14), we have been able to detect IAP related transcripts in rat cells. We found that, i) IAP related transcripts are poorly expressed in normal cells, since among 10 tissues tested, only the placenta shows IAP RNA. ii) IAPs are highly expressed in all the transformed cells tested. iii) the detected transcripts appear to have similar sizes in rat cells as in mouse cells (7.2 kb; 5.4 kb). None of the probes corresponding to other regions of the IAP gene nor the entire sequence of PMIA14 allowed us to detect such transcripts.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0006-291X
pubmed:author
pubmed:issnType
Print
pubmed:day
31
pubmed:volume
169
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
222-31
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Detection of IAP related transcripts in normal and transformed rat cells.
pubmed:affiliation
Rétrovirus et Rétrotransposons des Vertébrés, Hôpital Saint-Louis, Paris, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't