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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
15
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pubmed:dateCreated |
2006-9-27
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pubmed:abstractText |
Prostate cancer is frequently associated with bone metastases with marked osteoblastic changes and low osteoclastic activity but its mechanism is not well understood. We previously reported that prostate-specific antigen (PSA) stimulated the proliferation and the activation of osteoblasts. In this study, we investigated the effect of PSA on osteoclastogenesis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0270-4137
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
66
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1573-84
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pubmed:meshHeading |
pubmed-meshheading:16927388-Adenocarcinoma,
pubmed-meshheading:16927388-Aged,
pubmed-meshheading:16927388-Animals,
pubmed-meshheading:16927388-Apoptosis,
pubmed-meshheading:16927388-Bone Neoplasms,
pubmed-meshheading:16927388-Bone Transplantation,
pubmed-meshheading:16927388-Cell Line, Tumor,
pubmed-meshheading:16927388-Cell Proliferation,
pubmed-meshheading:16927388-Cell Survival,
pubmed-meshheading:16927388-DNA Fragmentation,
pubmed-meshheading:16927388-Disease Models, Animal,
pubmed-meshheading:16927388-Humans,
pubmed-meshheading:16927388-Male,
pubmed-meshheading:16927388-Mice,
pubmed-meshheading:16927388-Mice, Inbred NOD,
pubmed-meshheading:16927388-Mice, SCID,
pubmed-meshheading:16927388-Middle Aged,
pubmed-meshheading:16927388-Osteoblasts,
pubmed-meshheading:16927388-Osteoclasts,
pubmed-meshheading:16927388-Prostate-Specific Antigen,
pubmed-meshheading:16927388-Prostatic Neoplasms,
pubmed-meshheading:16927388-RNA, Messenger,
pubmed-meshheading:16927388-Specific Pathogen-Free Organisms,
pubmed-meshheading:16927388-Stem Cells,
pubmed-meshheading:16927388-Xenograft Model Antitumor Assays
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pubmed:year |
2006
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pubmed:articleTitle |
Prostate-specific antigen induces apoptosis of osteoclast precursors: potential role in osteoblastic bone metastases of prostate cancer.
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pubmed:affiliation |
Pathology Division, National Cancer Center Research Institute East, Chiba, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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