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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1990-6-20
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pubmed:abstractText |
Glomerular and tubular microproteinuria precede the development of overt nephropathy in Type 1 diabetes mellitus. However, in Type 2 diabetes urinary protein excretion and its relationship to diabetic nephropathy has not been clearly characterized. Twenty consecutive, newly diagnosed patients with Type 2 diabetes, whose urine was Albustix-negative and sterile on culture, were studied. Two timed overnight urine samples were collected at diagnosis, and after 2 months and 2 years, and excretion rates of albumin, alpha-1-microglobulin and N-acetyl-beta-D-glucosaminidase were calculated. HbA1c fell from 12.1 +/- 2.4% at diagnosis to 9.5 +/- 1.5% at 2 months and 9.6 +/- 2.2% at 2 years. Albumin excretion rate fell marginally from 6.5 (2.1-242.5) micrograms min-1 at diagnosis to 5.5 (1.7-274.0) micrograms min-1 at 2 months (p less than 0.05) rising again to 6.1 (1.9-201.7) micrograms min-1 at 2 years. alpha-1-Microglobulin excretion rate fell from 13.5 (3.6-59.9) micrograms min-1 at diagnosis to 8.4 (2.9-16.1) micrograms min-1 at 2 months and 8.8 (1.8-54.1) micrograms min-1 at 2 years (both p less than 0.05). Albumin excretion rate was found to correlate significantly with creatinine clearance at diagnosis (rs = 0.61, p less than 0.005), though not subsequently. In contrast, excretion rates of alpha-1-microglobulin and N-acetyl-beta-D-glucosaminidase correlated with HbA1c (rs = 0.68 and 0.66, respectively, p less than 0.005 at diagnosis and rs = 0.57 and 0.53, p less than 0.05 subsequently in both cases).(ABSTRACT TRUNCATED AT 250 WORDS)
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acetylglucosaminidase,
http://linkedlifedata.com/resource/pubmed/chemical/Alpha-Globulins,
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Creatinine,
http://linkedlifedata.com/resource/pubmed/chemical/Hemoglobin A, Glycosylated,
http://linkedlifedata.com/resource/pubmed/chemical/Protease Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/alpha-1-microglobulin
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0742-3071
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
315-8
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:1692521-Acetylglucosaminidase,
pubmed-meshheading:1692521-Albuminuria,
pubmed-meshheading:1692521-Alpha-Globulins,
pubmed-meshheading:1692521-Blood Glucose,
pubmed-meshheading:1692521-Blood Pressure,
pubmed-meshheading:1692521-Creatinine,
pubmed-meshheading:1692521-Diabetes Mellitus, Type 2,
pubmed-meshheading:1692521-Female,
pubmed-meshheading:1692521-Follow-Up Studies,
pubmed-meshheading:1692521-Hemoglobin A, Glycosylated,
pubmed-meshheading:1692521-Humans,
pubmed-meshheading:1692521-Male,
pubmed-meshheading:1692521-Middle Aged,
pubmed-meshheading:1692521-Protease Inhibitors,
pubmed-meshheading:1692521-Proteinuria
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pubmed:year |
1990
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pubmed:articleTitle |
Microproteinuria in type 2 diabetes mellitus from diagnosis.
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pubmed:affiliation |
University Department of Medicine, General Infirmary, Leeds, UK.
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pubmed:publicationType |
Journal Article
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