Linked Life Data

16922560

Source:http://linkedlifedata.com/resource/pubmed/id/16922560

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
18
pubmed:dateCreated
2006-8-22
pubmed:abstractText
We employed UV-induced template polymerization to create hollow nanometer-sized polymer capsules. Homogeneous, unilamellar liposomes served as a two-dimensional template for the cross-linking of either butyl methacrylate or hydroxyethyl methacrylate with the bifunctional ethyleneglycol dimethacrylate. Different molar ratios of lipid/hydrophobic monomer/bifunctional monomer/photoinitiator were tested and dynamic light scattering revealed negligible changes of size at a defined molar ratio of 2/1/10/20, respectively. Cryo-transmission electron microscopy provided clear evidence that incorporation of the methacrylate monomers into and polymerization in the hydrophobic bilayer phase does not disrupt vesicle integrity. Moreover, after solubilization of the lipids, the polymethacrylate nanocapsules were stable at conditions needed for negative staining and could be visualized by atomic force microscopy. In contrast to previous findings, the nanocapsule size and shape did not change considerably after removal of the template phase, and the size distribution remained strictly monomodal. The employed method is not only an advance to fortify liposomes, but the nanocapsules themselves can be functionalized.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0743-7463
pubmed:author
pubmed:issnType
Print
pubmed:day
29
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
7755-9
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Stable polymethacrylate nanocapsules from ultraviolet light-induced template radical polymerization of unilamellar liposomes.
pubmed:affiliation
Institut de Pharmacologie et Biologie Structurale CNRS UMR5089, Toulouse F-31077, France. j.gomes@iu-bremen.de
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't