| pubmed-article:16919608 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16919608 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:16919608 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:16919608 | lifeskim:mentions | umls-concept:C0004112 | lld:lifeskim |
| pubmed-article:16919608 | lifeskim:mentions | umls-concept:C0165519 | lld:lifeskim |
| pubmed-article:16919608 | lifeskim:mentions | umls-concept:C0597298 | lld:lifeskim |
| pubmed-article:16919608 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:16919608 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:16919608 | pubmed:dateCreated | 2006-9-11 | lld:pubmed |
| pubmed-article:16919608 | pubmed:abstractText | Matrix metalloproteinase-9 (MMP-9) may play a role in the inflammatory glial response during Alzheimer's disease (AD). Astrocytes can degrade beta-amyloid (Abeta) and extracellular proteolysis via MMP-9 may be involved. Because Apolipoprotein E (APOE) genotype is an important factor for AD, we ask whether various apoE isoforms can influence Abeta-induced MMP-9 responses in primary rat astrocytes. Our data show that apoE4 significantly dampens Abeta-induced MMP-9 levels, possibly by downregulating the Rho-Rho kinase (ROCK) pathway. Reduction of astrocytic MMP-9 by apoE4 may affect Abeta clearance and promote Abeta deposition in AD. | lld:pubmed |
| pubmed-article:16919608 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16919608 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16919608 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16919608 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16919608 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16919608 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16919608 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16919608 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16919608 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16919608 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16919608 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16919608 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16919608 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16919608 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16919608 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16919608 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16919608 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16919608 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:16919608 | pubmed:issn | 0006-8993 | lld:pubmed |
| pubmed-article:16919608 | pubmed:author | pubmed-author:KimWoo JeanWJ | lld:pubmed |
| pubmed-article:16919608 | pubmed:author | pubmed-author:FroschMatthew... | lld:pubmed |
| pubmed-article:16919608 | pubmed:author | pubmed-author:BacskaiBrian... | lld:pubmed |
| pubmed-article:16919608 | pubmed:author | pubmed-author:LoEng HEH | lld:pubmed |
| pubmed-article:16919608 | pubmed:author | pubmed-author:GreenbergStev... | lld:pubmed |
| pubmed-article:16919608 | pubmed:author | pubmed-author:GuoShuzhenS | lld:pubmed |
| pubmed-article:16919608 | pubmed:author | pubmed-author:LeeSun-RyungS... | lld:pubmed |
| pubmed-article:16919608 | pubmed:author | pubmed-author:WangSophiaS | lld:pubmed |
| pubmed-article:16919608 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16919608 | pubmed:day | 21 | lld:pubmed |
| pubmed-article:16919608 | pubmed:volume | 1111 | lld:pubmed |
| pubmed-article:16919608 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16919608 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16919608 | pubmed:pagination | 222-6 | lld:pubmed |
| pubmed-article:16919608 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:16919608 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16919608 | pubmed:articleTitle | Effects of apoE isoforms on beta-amyloid-induced matrix metalloproteinase-9 in rat astrocytes. | lld:pubmed |
| pubmed-article:16919608 | pubmed:affiliation | Department of Neurology, Mass General Hospital, Charlestown, MA, USA. | lld:pubmed |
| pubmed-article:16919608 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16919608 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16919608 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:81687 | entrezgene:pubmed | pubmed-article:16919608 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:16919608 | lld:entrezgene |
