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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2006-9-11
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pubmed:abstractText |
Matrix metalloproteinase-9 (MMP-9) may play a role in the inflammatory glial response during Alzheimer's disease (AD). Astrocytes can degrade beta-amyloid (Abeta) and extracellular proteolysis via MMP-9 may be involved. Because Apolipoprotein E (APOE) genotype is an important factor for AD, we ask whether various apoE isoforms can influence Abeta-induced MMP-9 responses in primary rat astrocytes. Our data show that apoE4 significantly dampens Abeta-induced MMP-9 levels, possibly by downregulating the Rho-Rho kinase (ROCK) pathway. Reduction of astrocytic MMP-9 by apoE4 may affect Abeta clearance and promote Abeta deposition in AD.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0006-8993
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
1111
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
222-6
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:16919608-Alzheimer Disease,
pubmed-meshheading:16919608-Amyloid beta-Peptides,
pubmed-meshheading:16919608-Animals,
pubmed-meshheading:16919608-Animals, Newborn,
pubmed-meshheading:16919608-Apolipoproteins E,
pubmed-meshheading:16919608-Astrocytes,
pubmed-meshheading:16919608-Brain,
pubmed-meshheading:16919608-Cells, Cultured,
pubmed-meshheading:16919608-Down-Regulation,
pubmed-meshheading:16919608-Gliosis,
pubmed-meshheading:16919608-Inflammation Mediators,
pubmed-meshheading:16919608-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:16919608-Matrix Metalloproteinase 9,
pubmed-meshheading:16919608-Plaque, Amyloid,
pubmed-meshheading:16919608-Protein Isoforms,
pubmed-meshheading:16919608-Protein-Serine-Threonine Kinases,
pubmed-meshheading:16919608-Rats,
pubmed-meshheading:16919608-Rats, Sprague-Dawley,
pubmed-meshheading:16919608-rho-Associated Kinases
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pubmed:year |
2006
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pubmed:articleTitle |
Effects of apoE isoforms on beta-amyloid-induced matrix metalloproteinase-9 in rat astrocytes.
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pubmed:affiliation |
Department of Neurology, Mass General Hospital, Charlestown, MA, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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