| pubmed-article:16914747 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16914747 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:16914747 | lifeskim:mentions | umls-concept:C0021758 | lld:lifeskim |
| pubmed-article:16914747 | lifeskim:mentions | umls-concept:C0242692 | lld:lifeskim |
| pubmed-article:16914747 | lifeskim:mentions | umls-concept:C0034963 | lld:lifeskim |
| pubmed-article:16914747 | lifeskim:mentions | umls-concept:C0074398 | lld:lifeskim |
| pubmed-article:16914747 | lifeskim:mentions | umls-concept:C0021665 | lld:lifeskim |
| pubmed-article:16914747 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:16914747 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:16914747 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:16914747 | lifeskim:mentions | umls-concept:C0443281 | lld:lifeskim |
| pubmed-article:16914747 | pubmed:issue | 17 | lld:pubmed |
| pubmed-article:16914747 | pubmed:dateCreated | 2006-8-17 | lld:pubmed |
| pubmed-article:16914747 | pubmed:abstractText | Serum response factor (SRF) is a crucial transcriptional factor for muscle-specific gene expression. We investigated SRF function in adult skeletal muscles, using mice with a postmitotic myofiber-targeted disruption of the SRF gene. Mutant mice displayed severe skeletal muscle mass reductions due to a postnatal muscle growth defect resulting in highly hypotrophic adult myofibers. SRF-depleted myofibers also failed to regenerate following injury. Muscles lacking SRF had very low levels of muscle creatine kinase and skeletal alpha-actin (SKA) transcripts and displayed other alterations to the gene expression program, indicating an overall immaturity of mutant muscles. This loss of SKA expression, together with a decrease in beta-tropomyosin expression, contributed to myofiber growth defects, as suggested by the extensive sarcomere disorganization found in mutant muscles. However, we observed a downregulation of interleukin 4 (IL-4) and insulin-like growth factor 1 (IGF-1) expression in mutant myofibers which could also account for their defective growth and regeneration. Indeed, our demonstration of SRF binding to interleukin 4 and IGF-1 promoters in vivo suggests a new crucial role for SRF in pathways involved in muscle growth and regeneration. | lld:pubmed |
| pubmed-article:16914747 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16914747 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16914747 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16914747 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16914747 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16914747 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16914747 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16914747 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16914747 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16914747 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16914747 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16914747 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16914747 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16914747 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16914747 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16914747 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16914747 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16914747 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16914747 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16914747 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16914747 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16914747 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16914747 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16914747 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16914747 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16914747 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16914747 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16914747 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16914747 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16914747 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16914747 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16914747 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16914747 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16914747 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16914747 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16914747 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16914747 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16914747 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16914747 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16914747 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16914747 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16914747 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16914747 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16914747 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16914747 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16914747 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16914747 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16914747 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16914747 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16914747 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16914747 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:16914747 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:16914747 | pubmed:author | pubmed-author:LiZhenlinZ | lld:pubmed |
| pubmed-article:16914747 | pubmed:author | pubmed-author:MelkiJudithJ | lld:pubmed |
| pubmed-article:16914747 | pubmed:author | pubmed-author:TuilDavidD | lld:pubmed |
| pubmed-article:16914747 | pubmed:author | pubmed-author:SchmittAlainA | lld:pubmed |
| pubmed-article:16914747 | pubmed:author | pubmed-author:DaegelenDomin... | lld:pubmed |
| pubmed-article:16914747 | pubmed:author | pubmed-author:SotiropoulosA... | lld:pubmed |
| pubmed-article:16914747 | pubmed:author | pubmed-author:HoubronChrist... | lld:pubmed |
| pubmed-article:16914747 | pubmed:author | pubmed-author:BertrandAnneA | lld:pubmed |
| pubmed-article:16914747 | pubmed:author | pubmed-author:ParlakianAraA | lld:pubmed |
| pubmed-article:16914747 | pubmed:author | pubmed-author:CharvetClaude... | lld:pubmed |
| pubmed-article:16914747 | pubmed:author | pubmed-author:GiordaniJulie... | lld:pubmed |
| pubmed-article:16914747 | pubmed:author | pubmed-author:LahouteCharlo... | lld:pubmed |
| pubmed-article:16914747 | pubmed:author | pubmed-author:RenouLaureL | lld:pubmed |
| pubmed-article:16914747 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16914747 | pubmed:volume | 26 | lld:pubmed |
| pubmed-article:16914747 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16914747 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16914747 | pubmed:pagination | 6664-74 | lld:pubmed |
| pubmed-article:16914747 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:16914747 | pubmed:meshHeading | pubmed-meshheading:16914747... | lld:pubmed |
| pubmed-article:16914747 | pubmed:meshHeading | pubmed-meshheading:16914747... | lld:pubmed |
| pubmed-article:16914747 | pubmed:meshHeading | pubmed-meshheading:16914747... | lld:pubmed |
| pubmed-article:16914747 | pubmed:meshHeading | pubmed-meshheading:16914747... | lld:pubmed |
| pubmed-article:16914747 | pubmed:meshHeading | pubmed-meshheading:16914747... | lld:pubmed |
| pubmed-article:16914747 | pubmed:meshHeading | pubmed-meshheading:16914747... | lld:pubmed |
| pubmed-article:16914747 | pubmed:meshHeading | pubmed-meshheading:16914747... | lld:pubmed |
| pubmed-article:16914747 | pubmed:meshHeading | pubmed-meshheading:16914747... | lld:pubmed |
| pubmed-article:16914747 | pubmed:meshHeading | pubmed-meshheading:16914747... | lld:pubmed |
| pubmed-article:16914747 | pubmed:meshHeading | pubmed-meshheading:16914747... | lld:pubmed |
| pubmed-article:16914747 | pubmed:meshHeading | pubmed-meshheading:16914747... | lld:pubmed |
| pubmed-article:16914747 | pubmed:meshHeading | pubmed-meshheading:16914747... | lld:pubmed |
| pubmed-article:16914747 | pubmed:meshHeading | pubmed-meshheading:16914747... | lld:pubmed |
| pubmed-article:16914747 | pubmed:meshHeading | pubmed-meshheading:16914747... | lld:pubmed |
| pubmed-article:16914747 | pubmed:meshHeading | pubmed-meshheading:16914747... | lld:pubmed |
