Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
17
pubmed:dateCreated
2006-8-16
pubmed:abstractText
Antibodies to viral surface glycoproteins play a crucial role in immunity to measles by blocking both virus attachment and subsequent fusion with the host cell membrane. Here, we demonstrate that certain immunoglobulin G (IgG) antibodies can also enhance the entry of measles virus (MV) into monocytes and macrophages. Antibody-dependent enhancement of infectivity was observed in mouse and human macrophages using virions opsonized by a murine monoclonal antibody against the MV hemagglutinin (H) glycoprotein, polyclonal mouse anti-MV IgG, or diluted measles-immune human sera. Neither H-specific Fab fragments nor H-specific IgM could enhance MV entry in monocytes or macrophages, indicating involvement of a Fc gamma receptor (FcgammaR)-mediated mechanism. Preincubation with an anti-fusion protein (anti-F) monoclonal antibody or a fusion-inhibitory peptide blocked infection, indicating that a functional F protein was required for viral internalization. Classical complement pathway activation did not promote infection through complement receptors and inhibited anti-H IgG-mediated enhancement. In vivo, antibody-enhanced infection allowed MV to overcome a highly protective systemic immune response in preimmunized IfnarKo-Ge46 transgenic mice. These data demonstrate a previously unidentified mechanism that may contribute to morbillivirus pathogenesis where H-specific IgG antibodies promote the spread of MV infection among FcgammaR-expressing host cells. The findings point to a new model for the pathogenesis of atypical MV infection observed after immunization with formalin-inactivated MV vaccine and underscore the importance of the anti-F response after vaccination.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/16912303-10092962, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912303-10358769, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912303-10371500, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912303-10775604, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912303-10933705, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912303-10972291, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912303-11163231, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912303-11238860, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912303-11254706, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912303-11359846, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912303-11389012, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912303-11567982, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912303-1159329, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912303-11756976, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912303-11861619, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912303-11984600, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912303-12052561, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912303-12097558, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912303-12183422, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912303-12232827, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912303-12639986, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912303-12697441, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912303-12750267, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912303-12805454, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912303-12873767, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912303-12925847, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912303-14527283, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912303-14577918, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912303-14614851, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912303-15040582, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912303-15147716, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912303-15166451, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912303-15256464, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912303-15466106, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912303-15685166, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912303-15961518, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912303-16139658, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912303-2261126, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912303-2414919, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912303-2972065, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912303-514096, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912303-6072745, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912303-6864163, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912303-8371352, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912303-8423079, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912303-8515132, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912303-9166428, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912303-9199438, http://linkedlifedata.com/resource/pubmed/commentcorrection/16912303-9696838
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0022-538X
pubmed:author
pubmed:issnType
Print
pubmed:volume
80
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
8530-40
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
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