Linked Life Data

16910731

Source:http://linkedlifedata.com/resource/pubmed/id/16910731

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
17
pubmed:dateCreated
2006-8-16
pubmed:abstractText
The optimal formulation of coenzyme Q10 (CoQ10) nanoliposomes and the feasibility of production in a pilot scale were investigated. The nanoliposomes were prepared by ethanol injection and sonication techniques for a desired vesicle size in the laboratory. Optimization of formulation in the preparation of CoQ10 nanoliposomes was achieved by an orthogonal array design. The best formulation was found to be phospholipid/CoQ10/cholesterol/Tween 80 (2.5:1.2:0.4:1.8, w/w) with phosphate buffer solution (pH 7.4, 0.01 M) as the hydration media. The z-average diameter (D(z)) was about 68 nm. The encapsulation efficiency was greater than 95% with a retention ratio higher than 90% and a particle size change lower than 10% after storage at 4 degrees C in the dark for 90 days. CoQ10 incorporation resulted in a dramatic increase of the microviscosity of nanoliposomes and inhibited the peroxidation of phospholipid. The D(z) of CoQ10 nanoliposomes produced in a pilot scale was about 67 nm. Results suggest that the technology developed by this investigation is practical to produce the CoQ10 nanoliposomes with the expected encapsulation quality and stability not only in the laboratory but also in a pilot scale.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0021-8561
pubmed:author
pubmed:issnType
Print
pubmed:day
23
pubmed:volume
54
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6358-66
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Optimization in the preparation of coenzyme Q10 nanoliposomes.
pubmed:affiliation
School of Food Science and Technology, Southern Yangtze University, Wuxi, 214036, People's Republic of China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't