Linked Life Data

16909136

Source:http://linkedlifedata.com/resource/pubmed/id/16909136

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2006-8-30
pubmed:abstractText
NK105 is a micellar nanoparticle formulation designed to enhance the delivery of paclitaxel (PTX) to solid tumours. It has been reported to exert antitumour activity in vivo and to have reduced neurotoxicity as compared to that of free PTX. The purpose of this study was to investigate the radiosensitising effect of NK105 in comparison with that of PTX. Lewis lung carcinoma (LLC)-bearing mice were administered a single intravenous (i.v.) injection of PTX or NK105; 24 h after the drug administration, a proportion of the mice received radiation to the tumour site or lung fields. Then, the antitumour activity and lung toxicity were evaluated. In one subset of mice, the tumours were excised and specimens were prepared for analysis of the cell cycle distribution by flow cytometry. Combined NK105 treatment with radiation yielded significant superior antitumour activity as compared to combined PTX treatment with radiation (P=0.0277). On the other hand, a histopathological study of lung sections revealed no significant difference in histopathological changes between mice treated with PTX and radiation and those treated with NK105 and radiation. Flow-cytometric analysis showed that NK105-treated LLC tumour cells showed more severe arrest at the G2/M phase as compared to PTX-treated tumour cells. The superior radiosensitising activity of NK105 was thus considered to be attributable to the more severe cell cycle arrest at the G2/M phase induced by NK105 as compared to that induced by free PTX. The present study results suggest that further clinical trials are warranted to determine the efficacy and feasibility of combined NK105 therapy with radiation.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/16909136-10210547, http://linkedlifedata.com/resource/pubmed/commentcorrection/16909136-10561343, http://linkedlifedata.com/resource/pubmed/commentcorrection/16909136-10669675, http://linkedlifedata.com/resource/pubmed/commentcorrection/16909136-10754992, http://linkedlifedata.com/resource/pubmed/commentcorrection/16909136-10832826, http://linkedlifedata.com/resource/pubmed/commentcorrection/16909136-10863062, http://linkedlifedata.com/resource/pubmed/commentcorrection/16909136-11734597, http://linkedlifedata.com/resource/pubmed/commentcorrection/16909136-11777631, http://linkedlifedata.com/resource/pubmed/commentcorrection/16909136-12047471, http://linkedlifedata.com/resource/pubmed/commentcorrection/16909136-12603378, http://linkedlifedata.com/resource/pubmed/commentcorrection/16909136-12610186, http://linkedlifedata.com/resource/pubmed/commentcorrection/16909136-12631594, http://linkedlifedata.com/resource/pubmed/commentcorrection/16909136-1350755, http://linkedlifedata.com/resource/pubmed/commentcorrection/16909136-13980636, http://linkedlifedata.com/resource/pubmed/commentcorrection/16909136-15005281, http://linkedlifedata.com/resource/pubmed/commentcorrection/16909136-15547180, http://linkedlifedata.com/resource/pubmed/commentcorrection/16909136-15752883, http://linkedlifedata.com/resource/pubmed/commentcorrection/16909136-15785749, http://linkedlifedata.com/resource/pubmed/commentcorrection/16909136-16222314, http://linkedlifedata.com/resource/pubmed/commentcorrection/16909136-1646194, http://linkedlifedata.com/resource/pubmed/commentcorrection/16909136-1656827, http://linkedlifedata.com/resource/pubmed/commentcorrection/16909136-1972736, http://linkedlifedata.com/resource/pubmed/commentcorrection/16909136-2004104, http://linkedlifedata.com/resource/pubmed/commentcorrection/16909136-2169587, http://linkedlifedata.com/resource/pubmed/commentcorrection/16909136-2384160, http://linkedlifedata.com/resource/pubmed/commentcorrection/16909136-2692843, http://linkedlifedata.com/resource/pubmed/commentcorrection/16909136-2946403, http://linkedlifedata.com/resource/pubmed/commentcorrection/16909136-3366935, http://linkedlifedata.com/resource/pubmed/commentcorrection/16909136-5924188, http://linkedlifedata.com/resource/pubmed/commentcorrection/16909136-599063, http://linkedlifedata.com/resource/pubmed/commentcorrection/16909136-7627965, http://linkedlifedata.com/resource/pubmed/commentcorrection/16909136-7635778, http://linkedlifedata.com/resource/pubmed/commentcorrection/16909136-7692001, http://linkedlifedata.com/resource/pubmed/commentcorrection/16909136-7729728, http://linkedlifedata.com/resource/pubmed/commentcorrection/16909136-7733649, http://linkedlifedata.com/resource/pubmed/commentcorrection/16909136-7885406, http://linkedlifedata.com/resource/pubmed/commentcorrection/16909136-7912167, http://linkedlifedata.com/resource/pubmed/commentcorrection/16909136-7940982, http://linkedlifedata.com/resource/pubmed/commentcorrection/16909136-8098270, http://linkedlifedata.com/resource/pubmed/commentcorrection/16909136-8866658, http://linkedlifedata.com/resource/pubmed/commentcorrection/16909136-9007127, http://linkedlifedata.com/resource/pubmed/commentcorrection/16909136-9539573, http://linkedlifedata.com/resource/pubmed/commentcorrection/16909136-9717821, http://linkedlifedata.com/resource/pubmed/commentcorrection/16909136-9779707
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0007-0920
pubmed:author
pubmed:issnType
Print
pubmed:day
4
pubmed:volume
95
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
601-6
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
NK105, a paclitaxel-incorporating micellar nanoparticle, is a more potent radiosensitising agent compared to free paclitaxel.
pubmed:affiliation
Investigative Treatment Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba 277-8577, Japan.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't